Results 131 to 140 of about 19,556,327 (384)
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Understanding further education as a context for public health intervention: qualitative findings from a study process evaluation. [PDF]
J Public Health (Oxf), 2020 Langford R, Willmott M, Fletcher A.
europepmc +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Efficacy and safety of Viltepso® in Duchenne muscular dystrophy: review of clinical studies
Русский журнал детской неврологииThe author presents a literature review on the safety and efficacy of antisense oligonucleotides in the treatment of Duchenne muscular dystrophy using the exon skipping method using Viltepso® (viltolarsen), the only drug of this class registered in ...
V. M. Suslov, D. I. Rudenko
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Role of Toll-like receptors polymorphisms in the development of extremely severe COVID-19
Инфекция и иммунитетCOVID-19 is a respiratory disease caused by the SARS-CoV-2 virus that can proceed to acute respiratory distress syndrome (ARDS) and trigger immunopathological mechanisms that lead to excessive inflammation.
Lyudmila A. Ashchina +3 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A clinical case of meningoencephalitis caused by achlorophyllum aquaticum Prototeca spp.
Журнал инфектологииProtothecosis is a rare infectious disease caused by non-photosynthetic algae belonging to the genus Prototheca. Its clinical manifestations may be acute or chronic, localized or generalized.
E. V. Tokareva +6 more
doaj +1 more source