Results 181 to 190 of about 41,636 (216)

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

A Case of Cytokine Release Syndrome (CRS) Related to Treatment With Lenvatinib Plus Pembrolizumab for Metastatic Clear Cell Renal Cell Carcinoma

open access: yesIJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infection and immunotherapy. Due to its nonspecific presentation, distinguishing CRS from other life‐threatening conditions remains challenging.
Kei Nagase   +9 more
wiley   +1 more source

Large Language Models in Preclinical Spine Research: A Scoping Review and Expert Perspective on Evidence‐Aware Experimental Workflows

open access: yesJOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Preclinical spine research is limited by heterogeneous experimental reporting, fragmented documentation, and barriers to reproducibility and translational alignment. Large language models (LLMs) and related artificial intelligence (AI) technologies may support semantic interpretation, structured data extraction, and reasoning over ...
Siegmund Lang   +5 more
wiley   +1 more source

Semi‐Automated μCT‐Based Modeling of Vertebral Bony Endplate Microporosity and Mechanical Properties: Linking Microstructure to Inferred Mechanical Performance

open access: yesJOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The vertebral bony endplate (BEP) plays a role in regulating both mechanical load transfer and nutrient transport to the intervertebral disc, functions strongly influenced by its microstructural porosity. Variations in porosity impact bone strength, elasticity, and solute diffusion, affecting its overall mechanical competence ...
Ahmad Alminnawi   +5 more
wiley   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

open access: yesJOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche   +9 more
wiley   +1 more source

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