Results 151 to 160 of about 3,882,403 (320)
Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceThe separatrix operational space of next-step fusion experiments: From ASDEX Upgrade data to SPARC scenarios
Nuclear Materials and EnergyFusion power plants require ELM-free, detached operation to prevent divertor damage and erosion. The separatrix operational space (SepOS) is proposed as a tool for identifying access to the type-I ELM-free quasi-continuous exhaust regime.T. Eich, T. Body, M. Faitsch, O. Grover, M.A. Miller, P. Manz, T. Looby, A.Q. Kuang, A. Redl, M. Reinke, A.J. Creely, D. Battaglia, J. Hillesheim, M. Wigram, J.W. Hughes +14 moredoaj +1 more sourceMolecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed +12 morewiley +1 more sourceTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceLawson Criterion for Ignition Exceeded In An Inertial Fusion Experiment
International Conference on Plasma Science, 2022 H. Abu-Shawareb, R. Acree, P. Adams, J. Adams, B. Addis, R. Aden, P. Adrian, B. Afeyan, M. Aggleton, L. Aghaian, A. Aguirre, D. Aikens, J. Akre, F. Albert, M. Albrecht, B. Albright, J. Albritton, J. Alcalá, C. Alday, D. Alessi, N. Alexander, J. Alfonso, N. Alfonso, E. Alger, Samim Ali, Z. Ali, W. Alley, P. Amala, P. Amendt, P. Amick, S. Ammula, C. Amorin, D. Ampleford, R. Anderson, T. Anklam, N. Antipa, B. Appelbe, C. Aracne-Ruddle, E. Araya, M. Arend, P. Arnold, T. Arnold, J. Asay, L. Atherton, D. Atkinson, R. Atkinson, J. Auerbach, B. Austin, L. Auyang, A. Awwal, J. Ayers, S. Ayers, T. Ayers, S. Azevedo, B. Bachmann, C. Back, J. Bae, D. Bailey, J. Bailey, T. Baisden, K. Baker, H. Baldis, D. Barber, M. Barberis, D. Barker, A. Barnes, C. Barnes, M. Barrios, C. Barty, I. Bass, S. Batha, S. Baxamusa, G. Bazán, J. Beagle, R. Beale, B. Beck, J. B. Beck, M. Bedzyk, R. Beeler, W. Behrendt, L. Belk, P. Bell, M. Belyaev, J. Benage, G. Bennett, L. Benedetti, L. Benedict, R. Berger, T. Bernat, L. Bernstein, B. Berry, L. Bertolini, G. Besenbruch, J. Betcher, R. Bettenhausen, R. Betti, B. Bezzerides, S. Bhandarkar, R. Bickel, J. Biener, T. Biesiada, K. Bigelow, J. Bigelow-Granillo, V. Bigman, R. Bionta, N. Birge, M. Bitter, A. Black, R. Bleile, D. Bleuel, E. Bliss, B. Blue, T. Boehly, K. Boehm, C. Boley, R. Bonanno, E. Bond, T. Bond, M. Bonino, M. Borden, J. Bourgade, J. Bousquet, J. Bowers, M. Bowers, R. Boyd, A. Bozek, D. Bradley, K. Bradley, P. A. Bradley, L. Bradley, L. Brannon, P. Brantley, D. Braun, T. Braun, K. Brienza-Larsen, T. Briggs, J. Britten, E. D. Brooks, D. Browning, M. Bruhn, T. Brunner, H. Bruns, G. Brunton, B. Bryant, T. Buczek, J. Bude, L. Buitano, S. Burkhart, J. Burmark, A. Burnham, R. Burr, L. Busby, B. Butlin, R. Cabeltis, M. Cable, W. Cabot, B. Cagadas, J. Caggiano, R. Cahayag, S. Caldwell, S. Calkins, D. Callahan, J. Calleja-Aguirre, L. Camara, D. Camp, E. Campbell, J. H. Campbell, B. Carey, R. Carey, K. Carlisle, L. Carlson, L. Carman, J. Carmichael, A. Carpenter, C. Carr, J. Carrera, D. Casavant, A. Casey, D. Casey, A. Castillo, E. Castillo, J. Castor, C. Castro, W. Caughey, R. Cavitt, J. Celeste, P. Celliers, C. Cerjan, G. Chandler, B. Chang, C. Chang, J. Chang, L. Chang, R. Chapman, T. Chapman, L. Chase, H. Chen, H. Chen, K. Chen, L.Y. Chen, B. Cheng, J. Chittenden, C. Choate, J. Chou, R. Chrien, M. Chrisp, K. Christensen, M. Christensen, A. Christopherson, M. Chung, J. Church, A. Clark, D. Clark, K. Clark, R. Clark, L. Claus, B. Cline, J. Cline, J. Cobble, K. Cochrane, B. Cohen, S. Cohen, M. Collette, Gilbert W. Collins, L. A. Collins, T. Collins, A. Conder, B. Conrad, M. Conyers, A. Cook, D. Cook, R. Cook, J. Cooley, G. Cooper, T. Cope, S. Copeland, F. Coppari, J. Cortez, J. Cox, D. Crandall, J. Crane, R. S. Craxton, M. Cray, A. Crilly, J. Crippen, D. Cross, M. Cuneo, G. Cuotts, C. E. Czajka, D. Czechowicz, T. Daly, P. Danforth, R. Darbee, B. Darlington, P. Datte, L. Dauffy, G. Dávalos, S. Davidovits, P. Davis, J. Davis, S. Dawson, R. Day, T. Day, M. Dayton, C. Deck, C. Decker, C. Deeney, K. Defriend, G. Deis, N. Delamater, J. Delettrez, R. Demaret, S. Demos, S. M. Dempsey, R. Desjardin, T. Desjardins, M. Desjarlais, E. Dewald, J. DeYoreo, S. Diaz, G. Dimonte, T. Dittrich, L. Divol, S. Dixit, J. Dixon, E. Dodd, D. Dolan, A. Donovan, M. Donovan, T. Döppner, C. Dorrer, N. Dorsano, M. Douglas, D. Dow, J. Downie, E. Downing, M. Dozières, V. Draggoo, D. Drake, R. P. Drake, T. Drake, G. Dreifuerst, D. Dubois, P. Dubois, G. Dunham, R. Dylla‐Spears, A. Dymoke-Bradshaw, B. Dzenitis, C. Ebbers, M. Eckart, S. Eddinger, D. Eder, D. Edgell, M. Edwards, P. Efthimion, J. Eggert, B. Ehrlich, P. Ehrmann, S. Elhadj, C. Ellerbee, N. Elliott, C. Ellison, F. Elsner, M. Emerich, K. Engelhorn, T. England, E. English, P. Epperson, R. Epstein, G. Erbert, M. A. Erickson, D. Erskine, A. Erlandson, R. J. Espinosa, C. Estes, K. Estabrook, S. Evans, A. Fabyan, J. Fair, R. Fallejo, N. Farmer, W. Farmer, M. Farrell, V. Fatherley, M. Fedorov, E. Feigenbaum, M. Feit, W. Ferguson, Carlos Segovia Fernández, A. Fernandez-Pañella, S. Fess, J. Field, C. Filip, J. Fincke, T. Finn, S. Finnegan, R. Finucane, M. Fischer, A. Fisher, J. Fisher, B. Fishler, D. Fittinghoff, P. Fitzsimmons, M. Flegel, K. Flippo, J. Florio, J. Folta, P. Folta, L. Foreman, C. Forrest, A. Forsman, J. Fooks, M. Foord, R. Fortner, K. Fournier, D. Fratanduono, N. Frazier, T. Frazier, C. Frederick, M. S. Freeman, J. Frenje, D. Frey, G. Frieders, S. Friedrich, D. Froula, J. Fry, T. Fuller, J. Gaffney, S. Gales, B. L. Le Galloudec, K. L. Le Galloudec, A. Gambhir, L. Gao, W. Garbett, A. Garcia, C. Gates, E. Gaut, P. Gauthier, Z. Gavin, J. Gaylord, M. Geissel, F. Génin, J. Georgeson, H. Geppert-Kleinrath, V. Geppert-Kleinrath, N. Gharibyan, J. Gibson, C. Gibson, E. Giraldez, V. Glebov, S. Glendinning, S. Glenn, S. Glenzer, S. Goade, P. Gobby, S. R. Goldman, B. Golick, M. Gomez, V. Goncharov, D. Goodin, P. Grabowski, E. Grafil, P. Graham, J. Grandy, E. Grasz, F. Graziani, G. Greenman, J. Greenough, A. Greenwood, G. Gregori, T. Green, J. Griego, G. Grim, J. Grondalski, S. Gross, J. Guckian, N. Guler, B. Gunney, G. Guss, S. Haan, J. Hackbarth, L. Hackel, R. Hackel, C. Haefner, C. Hagmann, K. Hahn, S. Hahn, B. Haid, B. Haines, B. Hall, C. Hall, G. Hall, M. Hamamoto, S. Hamel, C. Hamilton, B. Hammel, J. Hammer, G. Hampton, A. Hamza, A. Handler, S. Hansen, D. Hanson, R. Haque, D. Harding, E. Harding, J. Hares, D. Harris, J. Harte, E. Hartouni, R. Hatarik, S. Hatchett, A. Hauer, M. Havre, R. Hawley, J. Hayes, J. Hayes, S. Hayes, A. Hayes-Sterbenz, C. Haynam, D. Haynes, D. Headley, A. Heal, J. Heebner, S. Heerey, G. Heestand, R. Heeter, N. Hein, C. Heinbockel, C. Hendricks, M. Henesian, J. Heninger, J. Henrikson, E. Henry, E. Herbold, M. Hermann, G. Hermes, J. Hernandez, V. Hernandez, M. Herrmann, H. Herrmann +499 moresemanticscholar +1 more source
