Results 151 to 160 of about 1,777,078 (318)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The Quest for Fusion Energy

open access: yes, 1997
A brief history of the magnetic fusion program from the point of view of a stellarator enthusiast who worked at a major tokamak laboratory.
"Johnson, L. John"
core  

Comparison of tracklet fusion and distributed Kalman filter for track fusion

open access: yes, 2022
8 S.In track fusion, the measurements of individual sensors for each target are processed to generate local state estimates, which are then fused to obtain the global state estimate for the target. When there is no process noise or the fusion rate equals
Chong, C.-Y.   +3 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Review of the mathematical foundations of data fusion techniques in surface metrology

open access: yes, 2015
The recent proliferation of engineered surfaces, including freeform and structured surfaces, is challenging current metrology techniques. Measurement using multiple sensors has been proposed to achieve enhanced benefits, mainly in terms of spatial ...
Wang, Jian   +4 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Multi Level Fusion of Competitive Sensors for Automotive Environment Perception

open access: yes, 2013
A reference sensor system, consisting of a multilayer laser scanner and a stereo camera system, is used for detecting vehicle surroundings. Via a novel multi level multi sensor fusion framework the heterogeneous sensor information can be fused on three ...
Kozempel, Karsten, Haberjahn, Mathias
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

An Overview of Classifier Fusion Methods

open access: yes, 2000
A number of classifier fusion methods have been recently developed opening an alternative approach leading to a potential improvement in the classification performance.
Ruta, Dymitr, Gabrys, Bogdan
core  

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