Results 191 to 200 of about 3,721,647 (391)

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

open access: yesFEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang   +5 more
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

Lawson Criterion for Ignition Exceeded In An Inertial Fusion Experiment

open access: yesInternational Conference on Plasma Science, 2022
H. Abu-Shawareb   +499 more
semanticscholar   +1 more source

Nuclear Fusion in Spirillum spp.

open access: bronze, 1957
Michael A. Williams   +1 more
openalex   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

open access: yesFEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada   +3 more
wiley   +1 more source

Type Fusion

open access: yes, 2011
Fusion is an indispensable tool in the arsenal of techniques for program derivation. Less well-known, but equally valuable is type fusion, which states conditions for fusing an application of a functor with an initial algebra to form another initial algebra. We provide a novel proof of type fusion based on adjoint folds and discuss several applications:
openaire   +3 more sources

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