Results 41 to 50 of about 5,280 (289)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Revista de Métodos Cuantitativos para la Economía y la Empresa, 2017 En la década de los noventa en el sector financiero se produjo un proceso sin precedentes de fusiones y adquisiciones en toda Europa. Esta tendencia se inició en Estados Unidos en los ochenta, extendiéndose rápidamente al continente europeo.
Jimber del Río, Juan Antonio +2 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
La contabilización del efecto impositivo en las fusiones [PDF]
, 2009 En este artículo repasamos los diferentes aspectos contables y fiscales de las fusiones, para lo cual nos apoyamos en la resolución de diferentes supuestos. Con el nuevo Plan General Contable, las fusiones se encuadran en el contexto de las combinaciones
Labatut Serer, Gregorio +1 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Evaluación de las fusiones empresariales en el Perú [PDF]
, 2020 Se entiende como fusiones empresariales al conjunto de acciones que combinan recursos de dos o más organizaciones con el objetivo de generar valor; éstas han evolucionado cada vez más y a mayor ritmo, convirtiéndose esta en una práctica frecuente y ...
Colla Quea, Jesus Antony
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Fusion peptides and the mechanism of viral fusion
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003 Segments of viral fusion proteins play an important role in viral fusion. They are defined by a number of criteria, including the sensitivity of this region of the viral fusion protein to loss of function as a consequence of mutation. In addition, small model peptides designed to mimic this segment of viral fusion proteins often have some membrane ...
openaire +2 more sources