Results 81 to 90 of about 12,040,686 (279)

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Research on Using FANP to Establish a Performance Assessment Model for Business Intelligence Systems [PDF]

مدیریت بهره وری, 2011
In today’s fast expanding business climate, the need for useful business information seems to be vital not only for achieving success but also for the survival of an organization.
Jalal Haghighat Monfared, Azadeh Rezaei
doaj  

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

A Conduction‐Nucleation‐Competition‐Guided 3D Adaptive Gradient Buffer for Dendrite‐Free All‐Solid‐State Lithium Metal Batteries

Advanced Science, EarlyView.
A self‐adaptive gradient SCMN buffer layer is designed based on a conduction‐nucleation competition mechanism. The design dynamically optimizes ion/electron conduction and lithiophilicity, guiding dendrite‐free lithium deposition. Consequently, symmetric cells deliver exceeding 1600h at 1.5 mA cm−2, and the LiCoO2‐based full cells exhibit 98.5 ...
Yaru Shi, Libin Hu, Qiuhong Li, Zheng Zhang, Shoushuang Huang, Bing Zhao, Yi Xu, Zhangjun Hu, Yong Jiang, Jiujun Zhang   +9 more
wiley   +1 more source

Operation Risk Assessment of Urban Dense Cable Passageway Based on Fuzzy-Analytic Hierarchy Process

Applied Sciences
With the acceleration of urbanization, the development and utilization of urban underground spaces are becoming increasingly frequent, and the potential risks in the operation of urban dense cable passage may pose a major threat to the security of the ...
Yongjie Nie, Daoyuan Chen, Shuai Zheng, Xiaowei Xu, Xilian Wang, Zhensheng Wu   +5 more
doaj   +1 more source

Selection of Vendor Based on Intuitionistic Fuzzy Analytical Hierarchy Process [PDF]

Advances in Operations Research, 2014
Business environment is characterized by greater domestic and international competitive position in the global market. Vendors play a key role in achieving the so-called corporate competition. It is not easy however to identify good vendors because evaluation is based on multiple criteria.
openaire   +3 more sources

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

Advanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu, Huixuan Xu, Li Lin, Fei Wang, Yaodong Ding, Shuangqiao Liao, Xingyu Chen, Jichen Wen, Hongqiang Zhao, Jing Hao, Weixiang Zhao, Gong Zhang, Shiguang Shan, Yong Zeng, Hu Han, Minxian Wang   +15 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Evaluation of Cultural and Creative Products of Jinshan Farmer Painting Using Fuzzy Analytic Hierarchy Process

Engineering Proceedings
We evaluated the cultural and creative products of Jinshan Farmer Painting in Shanghai, utilizing the fuzzy analytic hierarchy process (FAHP) to determine the key evaluation indicators. Through a literature review, we constructed a hierarchical framework
Chen Liu, Hong-Mei Dai, Yuan Shen, Yu-Xuan Liu   +3 more
doaj   +1 more source

Decision support for information systems management : applying analytic hierarchy process [PDF]

Decision-making in the field of information systems has become more complex due to a larger number of alternatives, multiple and sometimes conflicting goals, and an increasingly turbulent environment.
Huizingh, Eelko K.R.E., Vrolijk, Hans C.J.   +1 more
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