Results 191 to 200 of about 4,505,718 (403)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Optimized Model Predictive Controller Using Multi-Objective Whale Optimization Algorithm for Urban Rail Train Tracking Control. [PDF]

Biomimetics (Basel)
Wang L, Wang L, Chen Y.
europepmc   +1 more source

Optimum Design of Particulate Mulling Process by Hybrid System of Fuzzy Control and Adaptive Predictive Control

, 1992
Kazuhiko Terashima, Hiroyuki Nomura, Nobuyuki YAMAKITA, Eiichiro SASAGAWA   +3 more
openalex   +2 more sources

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Research on self-adaptive height adjustment control of shearer based on deep deterministic policy gradient. [PDF]

PLoS One
Wang Y, Wang X, Lin G, Zhao L, Liu X, Jia B, Wang Y, He J, Ma L.   +8 more
europepmc   +1 more source

Data‐Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties

Advanced Science, EarlyView.
A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong, Jiho Choi, Han Bi Park, Ji Woo Lee, Seo Yeon Bae, Byoung Soo Kim, ChangKyu Yoon, Jun Dong Park   +7 more
wiley   +1 more source

Path tracking control method for tracked agricultural vehicles based on slip-aware look-ahead point offset. [PDF]

Front Plant Sci
Liu H, Han Z, Yin J, Bao J, Mu J, Tan H, Liu X.   +6 more
europepmc   +1 more source

Stability Analysis of Fuzzy Control System by 3D Space Display

, 1994
Mikio Maeda, Eiji Fukumiya
openalex   +2 more sources

Research on Applications of Fuzzy Self-adaptive PID Control in Synchronous Control System Based on Electro-Hydraulic Proportional Technology [PDF]

, 2016
Jinsong Chen
openalex   +1 more source

Development and Experimental Analysis of a Fuzzy Grey Control System on Rapeseed Cleaning Loss [PDF]

, 2020
Xiaoyu Chai, Lizhang Xu, Yang Li, Jie Qiu, Yaoming Li, Liya Lv, Yahui Zhu   +6 more
openalex   +1 more source