PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su +7 more
wiley +1 more source
Hybrid fuzzy-MPC based multi-objective control strategy for fast charging of electric vehicles with advanced battery thermal management and renewable grid support. [PDF]
Yadav IC, Bajpai RS, Gupta S, Shukla A.
europepmc +1 more source
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang +9 more
wiley +1 more source
Adaptive observed-based backstepping control for quantized robot arms. [PDF]
Du Z, Tang H, Gao S, Cai Y.
europepmc +1 more source
Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM
Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An +8 more
wiley +1 more source
Adaptive fuzzy fault-tolerant control for coordinated driving of a six-wheel lunar rover with tracking error reduction. [PDF]
Sun DQ +5 more
europepmc +1 more source
Distinct Biotypes of Visual Perception in Major Depressive Disorder
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai +13 more
wiley +1 more source
Intelligent trajectory tracking in autonomous plantation robots using PSO-tuned nonlinear fuzzy PID, fuzzy PID, and conventional PID controllers. [PDF]
Hailu GL, Yatayew TT.
europepmc +1 more source
A molecular‐bridging heterogeneous interface engineering strategy is introduced to combine a polyhedral oligomeric silsesquioxane (POSS)‐based hard coating with a colorless polyimide (CPI)‐based flexible layer. The robust heterogeneous interface endows the integrated system with the superior properties of both layers and their synergistic ...
Huiyang Lu +5 more
wiley +1 more source
Enhancing MPPT performance of a grid-connected Doubly-Fed induction generator-based wind power plant using hybrid ANFIS-PI control strategy. [PDF]
Biyazne LW +3 more
europepmc +1 more source

