Results 261 to 270 of about 424,076 (355)

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

open access: yesAdvanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li   +13 more
wiley   +1 more source

Image Fusion for Super‐Resolution Mass Spectrometry Imaging of Plant Tissue

open access: yesAdvanced Science, EarlyView.
A loss controlled residual network (LCRN) workflow is developed for super‐resolution fusion of plant mass spectrometry imaging data. LCRN uses a novel edge perceptual loss metric to preserve complex plant tissue morphology. LCRN achieves up to 20‐fold magnification while effectively combining chemical information from mass spectrometry with ...
Yuchen Zou   +3 more
wiley   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu   +11 more
wiley   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo   +9 more
wiley   +1 more source

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