Results 91 to 100 of about 137,292 (318)

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Dual‐Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures

Advanced Science, EarlyView.
A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng, Hufei Wang, Ming Li, Jianpeng Gao, Xiao Liu, Chuyue Zhang, Pengfei Chi, Bo Li, Yuan Xve, Daoyang Fan, Zheng Wang, Jianheng Liu, Xing Wang, Licheng Zhang   +13 more
wiley   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

Advanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang, Xue Jiang, Bingrui Xiong, Jiayi Chen, Xin Liu, Siyuan Wang, Bofu Li, Mian Peng, Wei Li   +8 more
wiley   +1 more source

Hesitancy Fuzzy Graphs

Indian Journal of Science and Technology, 2015
Objectives: To remove the hesitation that appears in choosing membership degree of an element from some possible values. Methods: Through Intuitionistic Fuzzy Graph and Intuitionistic Double Layered Fuzzy Graph, we developed a new graph to represent the hesitancy degree.
J. Jon Arockiaraj, J. Jesintha Rosline, T. Pathinathan   +2 more
openaire   +2 more sources

SGCD: High‐Resolution Spatial Domain Characterization via Data Interpolation and Cell‐Type Deconvolution

Advanced Science, EarlyView.
SGCD presents a novel approach for tissue spatial domain identification by employing interpolation to estimate inter‐spot gene expression and deconvolution to resolve cell‐type composition in both sampled and interstitial regions. By integrating gene expression, cell type, and spatial coordinates within a graph contrastive learning framework, SGCD ...
Tianjiao Zhang, Shenghe Li, Ruolan Zhang, Hongfei Zhang, Zhongqian Zhao, Hao Sun, Zhenao Wu, Guohua Wang   +7 more
wiley   +1 more source

Fuzzy Computational Analysis of Fuzzy Tadpole Graph

Journal of Mathematics
In this paper, we explore the application of fuzzy topological indices to the fuzzy tadpole graph TA,B, a hybrid structure that combines the cyclic and path-like components within a fuzzy framework.
Shama Liaqat, Zeeshan Saleem Mufti, Yilun Shang   +2 more
doaj   +1 more source

A spherical fuzzy planar graph approach to optimize wire configuration in transformers

Frontiers in Physics
In this modern era, graph theory has become an integral part of science and technology. It has enormous applications in handling various design-based problems.
Hao Guan, Hao Guan, Saira Hameed, Sadaf, Aysha Khan, Jana Shafi   +5 more
doaj   +1 more source

Photovoltaic and Photomultiplication Dual‐Mode Near‐Infrared Organic Detectors with Large Dynamic Range for Intensive and Faint Light Sensing

Advanced Science, EarlyView.
A photovoltaic/photomultiplication dual‐mode organic photodetector is developed by integrating two different organic bulk‐heterojunctions, one introduces the photovoltaic effect, and the other triggers photomultiplication charge generation in the stacked device at different voltage polarities.
Xin Hu, Ning Li, Mingyang Ren, Yifan Ji, Hongmei Guo, Qian Chen, Xiubao Sui   +6 more
wiley   +1 more source

Searching for network modules

, 2018
When analyzing complex networks a key target is to uncover their modular structure, which means searching for a family of modules, namely node subsets spanning each a subnetwork more densely connected than the average.
A Lancichinetti, A Lancichinetti, AE Brower, B Adamcsek, B Bollobás, E Boros, GC Rota, Hao Wu, I Gilboa, I Gilboa, J Reichardt, J Vlasblom, J Wang, Jierui Xie, Jose B. Pereira-Leal, M Aigner, M Szalay-Bekő, MC Schmidt, MEJ Newman, MEJ Newman, MEJ Newman, MEJ Newman, MEJ Newman, R Diestel, R Sharan, R Stanley, Randolf Rotta, S Asur, S Fortunato, S Miyamoto, S Zhang, SE Schaeffer, T Nepusz, T Yu, Tom C. Freeman, U Brandes, X Lei, Y Li, YY Ahn   +38 more
core   +1 more source