Results 191 to 200 of about 489,851 (292)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

Threshold‐Voltage Modulation and N2O Plasma Passivation for Enhanced Retention and Memory Window in Capacitorless 2T0C DRAM Oxide Thin‐Film Transistors

open access: yesAdvanced Science, EarlyView.
Al:ITZO‐based capacitorless 2T0C DRAMs are realized by combining N2O plasma‐induced defect modulation with read‐transistor W/L optimization to suppress leakage and stabilize data storage. This device‐level engineering enables zero‐bias hold operation, retention times exceeding 1000 s, and a 13‐fold expansion of the memory window, demonstrating a ...
Chahwan Yang   +3 more
wiley   +1 more source

Molecular Sieve Promoted Growth of Ferroelectric Trilayer 3R‐MoS2 for Polarization‐Dependent Reconfigurable Optoelectronic Synapses

open access: yesAdvanced Science, EarlyView.
The noncentrosymmetric trilayer rhombohedral‐stacked MoS2 nanoflakes with enhanced sliding ferroelectric properties are synthesized via a molecular sieve‐assisted chemical vapor deposition process. The switchable polarization states, combined with the exceptional light/gate voltage modulated electrical properties of these nanoflakes, enable broadband ...
Qichao Xue   +11 more
wiley   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

open access: yesAdvanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su   +7 more
wiley   +1 more source

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

open access: yesAdvanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang   +9 more
wiley   +1 more source

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