Results 201 to 210 of about 529,358 (334)

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu   +13 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

open access: yesAdvanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng   +20 more
wiley   +1 more source

What Are the Recipes of an Entrepreneur's Subjective Well-Being? A Fuzzy-Set Approach for China. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Yang Z   +6 more
europepmc   +1 more source

Rapid Arbitrary‐Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment

open access: yesAdvanced Science, EarlyView.
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao   +17 more
wiley   +1 more source

vEMINR: Ultra‐Fast Isotropic Reconstruction for Volume Electron Microscopy With Implicit Neural Representation

open access: yesAdvanced Science, EarlyView.
vEMINR is an ultra‐fast isotropic reconstruction method for vEM based on implicit neural representation, achieving over tenfold faster reconstruction and higher accuracy on 11 datasets, showing strong potential for large‐scale vEM data processing.
Jibin Yang   +7 more
wiley   +1 more source

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