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Time- and Temperature-Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management. [PDF]

J Clin Lab Anal
Zhang L, Li M, Xie Z, Yao J, Cao Y, Chen L, Wang M.   +6 more
europepmc   +1 more source

Ablation of hemophilic FVIII inhibitors with FVIII priming, cyclophosphamide immune suppression, and rapid tapering of FVIII immune tolerance [PDF]

American Journal of Hematology, 2004
AbstractThe efficacy and toxicity of factor VIII (FVIII) priming, cyclophosphamide immune suppression, and rapid tapering of concurrent FVIII immune tolerance for subjects with hemophilic inhibitors were evaluated. Four subjects with hemophilic inhibitors were studied.
Nathan L Kobrinsky
exaly   +3 more sources

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A novel deletion of FVIII gene associated with variable levels of FVIII inhibitor*

European Journal of Haematology, 1992
Abstract: We describe a novel gross deletion of the factor VIII gene in 5 related patients with severe hemophilia A. The deletion extends from intron 15 to at least 8.5 kb beyond the 3′ end of the gene (at least 95 kb of extension), and is associated with variable levels of FVIII inhibitor in 4 of the patients.
M S, Figueiredo, F, Bernardi, M A, Zago
openaire   +2 more sources

T cell response to FVIII

Cellular Immunology, 2016
Several lines of evidence indicate that the immune response to Factor VIII (FVIII) in patients with hemophilia A is T cell-dependent. This review highlights the link between the epitope specificity of FVIII-specific T cells and their potential roles in different categories of patients.
Marc Jacquemin
exaly   +3 more sources

The role of VWF in the immunogenicity of FVIII

Thrombosis Research, 2008
Up to 33% of patients with severe haemophilia A develop inhibitory antibodies to factor VIM (FVIII) that can significantly impair treatment with FVIII. The plasma protein von Willebrand factor (VWF) binds to FVIII and is known to be important for the functioning of FVIII.
Sébastien, Lacroix-Desmazes, Yohann, Repessé, Srinivas V, Kaveri, Suryasarathi, Dasgupta   +3 more
openaire   +2 more sources

Immunologic studies on the relationship between FVIII related antigen and FVIII procoagulant activity

Thrombosis Research, 1980
Abstract FVIII was separated into LMW FVIII and HMW FVIII by gel chromatography in the presence of 0.25 M CaCl2 or by high salt elution of LMW FVIII from FVIII bound to anti-HMW FVIII-Sepharose. Specific antibodies were raised in rabbits against HMW FVIII and LMW FVIII.
J J Veltkamp, R M Bertina
exaly   +3 more sources

Plasma-derived and recombinant FVIII

Blood, 2009
While plasma-derived and recombinant coagulation FVIII may largely share the same amino acid sequence and restore coagulation equally well, Qadura and colleagues demonstrate in this issue of Blood that these molecules appear quite different to the immune system.
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High factor VIII (FVIII) levels in venous thromboembolism: role of unbound FVIII

Thrombosis and Haemostasis, 2004
SummaryTheoretically, von Willebrand factor (VWF) should be capable of binding all factor VIII (FVIII), but an unbound FVIII (uFVIII) plasma fraction remains. In patients’ status post deep-vein thrombosis (DVT), an altered uFVIII fraction and high FVIII levels might be indicative of dysfunctional FVIII regulation.
Christian M, Schambeck, Ralf, Grossmann, Sarah, Zonnur, Mario, Berger, Kathleen, Teuchert, Alois, Spahn, Ulrich, Walter   +6 more
openaire   +2 more sources

FVIII, CD4, and liaisons dangereuses

Blood, 2011
In this issue of Blood , Hay and colleagues report the previously unrecognized bimodal distribution of hemophilia factor VIII inhibitor antibodies, peaking both in early childhood and in older age,[1][1] raising critical questions regarding our understanding of inhibitor formation ...
openaire   +2 more sources