Results 71 to 80 of about 16,303 (230)

Bo2C11 binding to FVIII in presence of dimeric anti-FVIII antibody-specific DARPins.

, 2013
Inhibition of anti-FVIII antibody (Bo2C11) binding was performed at the EC50 value of Bo2C11 on FVIII. 800 ng/ml Bo2C11 was mixed 1∶1 with increasing concentrations of eBo01-38 (black circles), eBo38-01 (black triangles), eBo38-38 (black squares) or a ...
Michael P. Horn (405688), Stefanie Hausammann (405684), Sebastien Lacroix-Desmazes (2291434), Monique Vogel (405685), Johanna A. Kremer Hovinga (405686), Beda M. Stadler (405687)   +5 more
core   +1 more source

Systemic Transcriptional Responses to Hemarthrosis and FVIII Replacement in FVIII-Deficient Mice

Blood, 2018
Abstract Introduction Hemarthrosis in patients with hemophilia (PWH) leads to local inflammation and vascular changes in the joint, but little is known about the extent and nature of systemic responses to joint bleeding.
Esther J Cooke, Srila Gopal, John Shimashita, Chanond A Nasamran, Kathleen M Fisch, Laurent O Mosnier, Annette von Drygalski   +6 more
openaire   +1 more source

From Bleeding Control to Health: Implementing Multidimensional and Multidisciplinary Hemophilia Care Into the Era of Therapeutic Innovation

Haemophilia, EarlyView.
ABSTRACT Introduction Over the past decade, hemophilia management has been transformed by modern prophylactic strategies, achieving dramatic reductions in annualized bleeding rates (ABR), often approaching zero. However, the conceptual evolution of hemophilia care toward multidimensional health assessment and comprehensive multidisciplinary management ...
Nicolas Giraud, Yesim Dargaud
wiley   +1 more source

Flow Cytometry Evaluation of Blood-Cell-Bound Surface FVIII in Hemophilia A and Thrombosis

Cells
Hemophilia A (HA) is associated with FVIII coagulation insufficiency or inactivity leading to excessive bleeding. Elevated FVIII, on the contrary, is associated with thrombophilia, thrombosis, myocardial infarctions, and stroke.
Anjud Al-Mohannadi, Reem Mohammed Yahia, Hani Bibawi, Che-Ann Lachica, Watfa Ahmed, Igor Pavlovski, Giusy Gentilcore, Elkhansa Elbukhari Elgaali, Anila Ejaz, Areeg Ahmed, Mohammed Elanbari, Zainab Awada, Mohammed J. Al-Kubaisi, Muhammad Elnaggar, Ayman Saleh, Chiara Cugno, Sara Deola   +16 more
doaj   +1 more source

Perioperative von Willebrand Factor and Factor VIII Kinetics in von Willebrand Disease Patients Treated With Different Clotting Factor Concentrates

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with von Willebrand disease (VWD) undergoing surgery require von Willebrand factor (VWF) and factor VIII (FVIII) supplementation for adequate haemostasis. Plasma‐derived clotting factor concentrates differ in their VWF:FVIII activity ratios: high‐ratio product (HRP, 10:1), intermediate‐ratio product (IRP, 2.4:1), and low ...
Zoë A. Gras, Geoffrey Z. L. Kuppens, Roger E. G. Schutgens   +2 more
wiley   +1 more source

Type 2 conventional dendritic cells mediate FVIII recognition in FVIII immune response 2256433

Introduction Hemophilia A is an X-linked bleeding disorder caused by mutations in the F8 gene, leading to a deficiency of coagulation factor VIII (FVIII).
Mengjie Kong, Glaivy Batsuli
core   +1 more source

Pharmacokinetics, coagulation factor consumption and clinical efficacy in patients being switched from full-length FVIII treatment to B-domain-deleted r-FVIII and back to full-length FVIII

, 2009
Concerns have been raised regarding pharmacokinetic performance, efficacy and safety of B-domain-deleted recombinant FVIII (BDD rFVIII). The objective of this study was to perform a retrospective survey of half-life measurements, efficacy and safety in ...
Dunkerley, A., Sørensen, B., Rangarajan, S., Rea, C.   +3 more
core   +1 more source

Population‐Level Real‐World Healthcare Costs in Men and Women With Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Even with modern prophylaxis options, people living with haemophilia have significantly lower quality of life and joint health outcomes than those without. Aim Our goal was to determine if real‐world health‐system costs are higher for people living with haemophilia A compared to those without and determine how joint‐health state ...
Sam Hirniak, Samantha S. M. Drover, Andrea N. Edginton, Dagmar M. Hajducek, Alfonso Iorio, Mhd. Wasem Alsabbagh, William W. L. Wong   +6 more
wiley   +1 more source

Characteristics of anti-fVIII MAbs.

, 2012
Characteristics of anti-fVIII MAbs.
Bagirath Gangadharan (124016), Christopher B. Doering (124019), Shannon L. Meeks (124024), Bhavya S. Doshi (124012)   +3 more
core   +1 more source

Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice

Bone Research
In addition to its role in hemostasis, Factor VIII (FVIII) has recently been shown to potentially impact angiogenesis, inflammation, osteopenia, and sarcopenia. This was explored here by studying the musculoskeletal development of FVIII knockout (FVIII -/
Antoine Babuty, Javier Muñoz-Garcia, Olivier D. Christophe, Laurie Fradet, Manon Taupin, Denis Cochonneau, Emilie Ollivier, Frank Driessler, Claudia Lange, Oleksandr Boychenko, Marie-Françoise Heymann, Dominique Heymann   +11 more
doaj   +1 more source