Results 231 to 240 of about 40,710 (290)

Current Drug Development Pipeline for MASLD and MASH: Focusing on Cardiovascular Comorbidities. [PDF]

Biomedicines
Prikhodko VA, Okovityi SV.
europepmc   +1 more source

Microbial transformation of secondary bile acids: roles in gut ecology and autoimmune diseases. [PDF]

Front Immunol
Ren L, Li M, Wu L, Lin Z, Chen A.
europepmc   +1 more source

LC2767 alleviates LPS-induced liver injury and fibrosis by regulating FXR expression, NF-κB activation, and gut microbiota. [PDF]

Sci Rep
Lee DY, Jang HM, Shin JW, Shin YJ, Kim SH, Han SW, Kim DH.   +6 more
europepmc   +1 more source

Interplay between circadian rhythms, gut microbiota, and MASLD: from mechanistic foundations to therapeutic opportunities. [PDF]

Front Med (Lausanne)
Chen YJ, Yang BW, Gu ZC, Han J.
europepmc   +1 more source

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Immunomodulatory functions of FXR.

Molecular and Cellular Endocrinology, 2022
The Farnesoid-x-receptor (FXR) is a bile acids sensor activated in humans by primary bile acids. FXR is mostly expressed in liver, intestine and adrenal glands but also by cells of innate immunity, including macrophages, liver resident macrophages, the ...
S. Fiorucci, A. Zampella, P. Ricci, E. Distrutti, M. Biagioli   +4 more
semanticscholar   +4 more sources

Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis

Immunity
Necrotizing enterocolitis (NEC) is a common pediatric emergency primarily afflicting preterm infants, yet its mechanisms remain to be fully understood.
Qiang Liu, Jie Zhou
exaly   +2 more sources

Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress

Cell Metabolism
Bile acid (BA) homeostasis is vital for various physiological processes, whereas its disruption underlies cholestasis. The farnesoid X receptor (FXR) is a master regulator of BA homeostasis via the ileal fibroblast growth factor (FGF)15/19 endocrine ...
Zhifeng Huang
exaly   +2 more sources

HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter

Metabolism: Clinical and Experimental, 2018
Farnesoid X receptor (FXR) as a member of nuclear receptor is tightly associated with glucose metabolism. Accumulated evidence has addressed the potential of FXR antagonist in the treatment of type 2 diabetes mellitus (T2DM), although the related mechanisms remain unclear.
Jiaying Wang, Xing Xu, Lihong Hu
exaly   +3 more sources