Results 241 to 250 of about 40,710 (290)

FXR ligand structure impact on FXR‐DNA binding

The FASEB Journal, 2022
The farnesoid X‐receptor (FXR), a nuclear receptor, is a ligand‐regulated transcription factor that regulates bile acid, lipid, and glucose metabolism. FXR consists of a ligand‐binding domain (LBD), that bind small lipophilic ligands, and a DNA binding domain (DBD) that targets specific areas of DNA called FXR response elements (FXRE).
Emily Meinert, Tracy Yu
openaire   +1 more source

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

Medicinal research reviews (Print), 2023
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver disease, is the most common liver disease worldwide and has no approved pharmacotherapy.
Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang   +4 more
semanticscholar   +1 more source

Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice

Journal of Pineal Research, 2022
Aflatoxin B1 (AFB1) is a widespread contaminant in foods and feedstuffs, and its target organ is the liver. Melatonin (MT) has been shown to alleviate inflammation in organs and remodel gut microbiota in animals and humans.
Shuiping Liu, W. Kang, Xinru Mao, Lei Ge, H. Du, Jinyan Li, Lili Hou, Dandan Liu, Yulong Yin, Yunhuan Liu, Kehe Huang   +10 more
semanticscholar   +1 more source

Aflatoxin B1 induces liver injury by disturbing gut microbiota-bile acid-FXR axis in mice.

Food and Chemical Toxicology, 2023
Aflatoxin B1 (AFB1) is one of major pollutant in food and feed worldwide. The purpose of this study is to investigate the mechanism of AFB1-induced liver injury.
Yunhuan Liu, Jinyan Li, W. Kang, Shuiping Liu, Jinyan Liu, Mengdie Shi, Yubo Wang, Xianjiao Liu, Xingxiang Chen, Kehe Huang   +9 more
semanticscholar   +1 more source

Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress.

Phytomedicine, 2023
BACKGROUND Cholestatic liver diseases (CLD) comprise a variety of disorders of bile formation, which causes chronic exposure to bile acid (BA) in the liver generally and results in hepatotoxicity and progressive hepatobiliary injury.
Meiqi Wang, Kaihui Zhang, Fangle Liu, Rui Zhou, Yu Zeng, Ali Chen, Yang Yu, Quan Xia, Chenchen Zhu, Chaozhan Lin   +9 more
semanticscholar   +1 more source

Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling.

Phytomedicine, 2023
BACKGROUND Alcoholic liver disease (ALD) is characterized by the disturbance of bile acids homeostasis, which further deteriorates ALD. Bile acid metabolism and its related signal molecules have become new therapeutic targets for alcoholic liver disease.
Li Xiao, Guangfu Xu, Silong Chen, Yumin He, Fan Peng, Chengfu Yuan   +5 more
semanticscholar   +1 more source

FXR: the key to benefits in bariatric surgery?

Nature Medicine, 2014
Bariatric surgery reduces the weight of morbidly obese individuals and exerts beneficial effects on associated metabolic disorders such as type 2 diabetes. However, despite growing traction in this area of metabolic research, questions remain as to the mechanisms that lead to these benefits.
Kuipers, Folkert, Groen, Albert K.
openaire   +3 more sources

Targeting FXR in Cholestasis

2019
The farnesoid X receptor (FXR, NR1H4) is a bile acid (BA)-activated transcription factor, which is essential for BA homeostasis. FXR and its hepatic and intestinal target genes, small heterodimer partner (SHP, NR0B2) and fibroblast growth factor 15/19 (Fgf15 in mice, FGF19 in humans), transcriptionally regulate BA synthesis, detoxification, secretion ...
Verena, Keitel, Carola, Dröge, Dieter, Häussinger   +2 more
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FXR, a multipurpose nuclear receptor

Trends in Biochemical Sciences, 2006
The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. In the past six years, remarkable inroads have been made into determining the functional importance of FXR. This receptor has been shown to have crucial roles in controlling bile acid homeostasis, lipoprotein and glucose ...
Florence Y, Lee, Hans, Lee, Melissa L, Hubbert, Peter A, Edwards, Yanqiao, Zhang   +4 more
openaire   +2 more sources

Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling.

Science
Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis.
Yuanheng Yang, Cong Hao, Tingying Jiao, Zidan Yang, Hui Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Chuying Sun, Tuo Yang, Jiatian Li, Jing Wu, Mengjiao Zhang, Yilun Wang, D. Xie, Ting Wang, Ning Wang, Xi Huang, Changjun Li, Frank J. Gonzalez, Jie Wei, Carol Xie, Chao Zeng, G. Lei   +23 more
semanticscholar   +1 more source