Results 251 to 260 of about 40,710 (290)

Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation

Nature Communications
Disruption of bile acid (BA) metabolism causes various liver diseases including hepatocellular carcinoma (HCC). However, the underlying molecular mechanism remains elusive. Here, we report that BA metabolism is directly controlled by a repressor function
Yuchen Liu, Juanjuan Zhu, Yu Jin, Zhonghe Sun, Xiaolin Wu, Huiping Zhou, Yingzi Yang   +6 more
semanticscholar   +1 more source

Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice.

Mechanisms of Ageing and Development, 2022
Sarcopenia is the age-related decrease in skeletal muscle mass, and current therapies for this disease are ineffective. We previously showed that ileal farnesoid X receptor (FXR)-fibroblast growth factor 15/19 (FGF15/19) signaling acts as a regulator of ...
Yixuan Qiu, Jiaming Yu, Xueying Ji, Huiyuan Yu, Mengjuan Xue, Fan Zhang, Yi Li, Z. Bao   +7 more
semanticscholar   +1 more source

FXR

2003
Bile acids (BAs) are synthesized from cholesterol exclusively by the liver. The biosynthetic steps that collectively accomplish the conversion of hydrophobic, water-insoluble cholesterol molecules into more water-soluble compounds also confer detergent properties to the BA that are crucial for their physiological functions in bile formation and ...
Claudel, T., Sturm, E., Staels, B., Kuipers, F.   +3 more
openaire   +2 more sources

Alisol B 23-acetate adjusts bile acid metabolisim via hepatic FXR-BSEP signaling activation to alleviate atherosclerosis.

Phytomedicine, 2022
BACKGROUND Postmenopausal women have a high incidence of atherosclerosis. Phytosterols have been shown to have cholesterol-lowering properties. Alisa B 23-acetate (AB23A) is a biologically active plant sterol isolated from Chinese herbal medicine Alisma.
Yu Fu, Han Feng, Xue Ding, Qinghai Meng, Shurui Zhang, Jun Li, Ying Chao, Tingting Ji, Yunhui Bi, Weiwei Zhang, Qi Chen, Yuhan Zhang, You-Long Feng, H. Bian   +13 more
semanticscholar   +1 more source

Regulation of bile acids and their receptor FXR in metabolic diseases

Frontiers in Nutrition
High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity and obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding and elucidation of the specific molecular
Yao Li, Lulu Wang, Qing Yi, L. Luo, Yuxia Xiong   +4 more
semanticscholar   +1 more source

Polyunsaturated Fatty Acids Are FXR Ligands and Differentially Regulate Expression of FXR Targets

DNA and Cell Biology, 2004
Polyunsaturated fatty acids (PUFAs) have been previously reported as agonists of peroxisome proliferatoractivated receptor and antagonists of the liver X receptor. The activities on these two nuclear receptors have been attributed to their beneficial effects such as improvement of dyslipidemia and insulin sensitivity and decrease of hepatic lipogenesis.
Annie, Zhao, Jinghua, Yu, Jane-L, Lew, Li, Huang, Samuel D, Wright, Jisong, Cui   +5 more
openaire   +2 more sources

Astragaloside IV ameliorates diet-induced hepatic steatosis in obese mice by inhibiting intestinal FXR via intestinal flora remodeling.

Phytomedicine, 2022
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a major clinical and public health burden worldwide with no established pharmacological therapy.
Yuanyuan Zhai, Wenling Zhou, Xuejing Yan, Yuan Qiao, Lingling Guan, Zhichun Zhang, H. Liu, Jizhi Jiang, Liang Peng   +8 more
semanticscholar   +1 more source

A Current Understanding of FXR in NAFLD: The multifaceted regulatory role of FXR and novel lead discovery for drug development.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has reached 30 %, with an annual increase. The incidence of NAFLD-induced cirrhosis is rapidly rising and has become the leading indicator for liver transplantation in the US.
Yuhong Tang, Yujuan Fan, Yiming Wang, Dong Wang, Qingyu Huang, Tongqing Chen, Xinyue Cao, Cailing Wen, Xiaoyan Shen, Jian Li, Yan You   +10 more
semanticscholar   +1 more source

Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders.

Biochemical Society Transactions, 2022
Intrahepatic cholestasis is the main feature of a group of liver diseases that are characterized by hepatic and systemic accumulation of bile acids due to impaired excretion of bile, based on inflammation of intrahepatic and extrahepatic bile ducts or ...
A. Molinaro, H. Marschall
semanticscholar   +1 more source

Dual Modulator of FXR and HSD17B13: Revitalizing FXR Therapies in MASH

Journal of Medicinal Chemistry
Dual modulation of FXR and HSD17B13 presents a promising strategy for treating metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatohepatitis (MASH). Compound 6, a groundbreaking dual modulator of FXR and HSD17B13, validates the concept of significantly enhancing liver function, reducing inflammation ...
Changhong Wei, Yun Liu, Zhiming Yan, Jing Han, Neng Jiang   +4 more
openaire   +2 more sources