Results 261 to 270 of about 40,710 (290)
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Gut, 2022
Objective Dysbiosis of the intestinal fungal community has been observed in inflammatory bowel disease (IBD); however, its potential role in IBD development and prevention remains unclear. Here, we explored the biological effects and molecular mechanisms
Xiaokui Huo +18 more
semanticscholar +1 more source
Objective Dysbiosis of the intestinal fungal community has been observed in inflammatory bowel disease (IBD); however, its potential role in IBD development and prevention remains unclear. Here, we explored the biological effects and molecular mechanisms
Xiaokui Huo +18 more
semanticscholar +1 more source
Zeitschrift für Physik A Hadrons and nuclei, 1968
The continuous radiation from a flash X-ray (FXR) discharge has been investigated when anodes made of Be, Al, Ta, W, and U are used. It is found that the heavier materials give rise to the strongest continuum. The continuous radiation in the 7–300 A and 2,000–5,000 A regions have been recorded and are shown in spectrograms.
A. Dejke, S. K. Händel
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The continuous radiation from a flash X-ray (FXR) discharge has been investigated when anodes made of Be, Al, Ta, W, and U are used. It is found that the heavier materials give rise to the strongest continuum. The continuous radiation in the 7–300 A and 2,000–5,000 A regions have been recorded and are shown in spectrograms.
A. Dejke, S. K. Händel
openaire +1 more source
Phytomedicine, 2022
BACKGROUND Previous studies have shown that the anti-cholestatic effect of oleanolic acid (OA) is associated with FXR and NRF2. However, how the two signaling pathways cooperate to regulate the anti-cholestatic effect of OA remains unclear.
Jianming Liu +6 more
semanticscholar +1 more source
BACKGROUND Previous studies have shown that the anti-cholestatic effect of oleanolic acid (OA) is associated with FXR and NRF2. However, how the two signaling pathways cooperate to regulate the anti-cholestatic effect of OA remains unclear.
Jianming Liu +6 more
semanticscholar +1 more source
Targeting FXR in cholestasis: hype or hope
Expert Opinion on Therapeutic Targets, 2014Bile acids, the end product of cholesterol metabolism, are signaling molecules. The farnesoid X receptor (FXR) is a bile acid sensor and is part of a network of nuclear receptors that regulate bile acid homeostasis. In addition to FXR, bile acids activate other nuclear receptors (CAR, PXR and VDR), cell surface receptors including the G protein-coupled
FIORUCCI, Stefano +5 more
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T0901317 is a dual LXR/FXR agonist
Molecular Genetics and Metabolism, 2004We characterize the ability of the liver X receptor (LXRalpha [NR1H3] and LXRbeta [NR1H2]) agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid.
Keith A, Houck +6 more
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FXR modulators for enterohepatic and metabolic diseases
Expert Opinion on Therapeutic Patents, 2018Farnesoid X receptor (FXR), a nuclear receptor mainly expressed in enterohepatic tissues, is a master for bile acid, lipid and glucose homeostasis. Additionally, it acts as a cell protector with unclear mechanism but may be implicated in combating against inflammation, fibrosis and cancers.
Hong, Wang +4 more
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Journal of steroid biochemistry and molecular biology, 2012
Cholestatic liver disorders encompass hepatobiliary diseases of diverse etiologies characterized by the accumulation of bile acids, bilirubin and cholesterol as the result of impaired secretion of bile. Members of the nuclear receptor (NR) family of ligand-modulated transcription factors are implicated in the adaptive response to cholestasis.
Jonker, Johan W. +2 more
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Cholestatic liver disorders encompass hepatobiliary diseases of diverse etiologies characterized by the accumulation of bile acids, bilirubin and cholesterol as the result of impaired secretion of bile. Members of the nuclear receptor (NR) family of ligand-modulated transcription factors are implicated in the adaptive response to cholestasis.
Jonker, Johan W. +2 more
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Association of FXR gene variants with cholelithiasis
Clinics and Research in Hepatology and Gastroenterology, 2015Impairment of bile acid homeostasis is the most important risk factor of gallstone disease. Thereby the bile acid sensor farnesoid X receptor (FXR) plays a pivotal role in hepatic and intestinal bile acid metabolism. In this explorative study, the FXR gene was investigated to identify gene variants, associated with gallstone formation in a Caucasian ...
Satoko, Hirobe-Jahn +5 more
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FXR modulators and cholestatic diseases | [Modulatori di FXR e patologie colestatiche]
2021The Farnesoid X nuclear receptor (FXR) is a nuclear receptor of bile acids whose activation suppresses the synthesis of bile acids stimulates their excretion in the bile and inhibits its uptake in hepatocytes. FXR is also involved in the regulation of over 250 genes including those responsible for the control of lipid and carbohydrate metabolism.
Alvaro D. +3 more
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Is the FXR the Fix for Cholesterol Gallstone Disease? *
Hepatology, 2005Abstract Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe the same phenotype in mice lacking the bile acid receptor, FXR.
Brian D, Juran +1 more
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