Results 271 to 280 of about 40,710 (290)

A novel intestinal-restricted FXR agonist

Bioorganic & Medicinal Chemistry Letters, 2017
In this study, a new intestinal-restricted FXR agonist named fexaramine-3 (Fex-3) was developed and investigated both in vitro and in vivo. Fex-3 could selectively activate intestinal FXR and promote the expression of BSEP and SHP while suppressing CYP7A1 which is involved in bile acids syntheses better than the reported intestinal-restricted FXR ...
Hong Wang, Zhou Zhao, Jiyu Zhou, Yitong Guo, Guangji Wang, Haiping Hao, Xiaowei Xu   +6 more
openaire   +2 more sources

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

Gastroenterology, 2003
Bile acids are essential for bile formation and intestinal absorption of lipids and fat-soluble vitamins. However, the intrinsic toxicity of hydrophobic bile acids demands a tight control of their intracellular concentrations. Bile acids are ligands for the farnesoid X receptor (FXR) that regulates the expression of genes controlling bile acid ...
Barbier, O, Pineda Torra, I., Sirvent, A, Claudel, T, Blanquart, C, Duran-Sandoval, D, Kuipers, F, Kosykh, V, Fruchart, JC, Staels, B   +9 more
openaire   +3 more sources

Statins and transcriptional regulation: The FXR connection

Biochemical and Biophysical Research Communications, 2005
Farnesoid X receptor (FXR) is a nuclear receptor involved in lipoprotein as well as glucose metabolism. Statins are widely used hypolipidemic agents with many pleiotropic actions. It is known that statins affect other nuclear hormone receptors, but no reports are available on the effect of these drugs on FXR. Employing an animal model (Syrian hamsters),
Ioannis, Habeos, Panos G, Ziros, Agathoklis, Psyrogiannis, Apostolos G, Vagenakis, Athanasios G, Papavassiliou   +4 more
openaire   +2 more sources

FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
The regulation of the rabbit apical sodium-dependent bile acid transporter (ASBT) was studied both in vivo and in vitro. New Zealand White rabbits were fed 0.5% deoxycholic acid (DCA) or SC-435, a competitive ASBT inhibitor, for 1 wk. In DCA-fed rabbits, ASBT expression was repressed, associated with activated FXR, and evidenced by increased ileal ...
Hai, Li, Frank, Chen, Quan, Shang, Luxing, Pan, Benjamin L, Shneider, John Y L, Chiang, Barry M, Forman, M, Ananthanarayanan, G Stephen, Tint, Gerald, Salen, Guorong, Xu   +10 more
openaire   +2 more sources

FXR crosstalk with other nuclear receptors

Journal of Physiology and Biochemistry
The farnesoid X receptor (FXR), a nuclear receptor (NR), plays a key role in balancing bile acid (BA), lipid, and glucose metabolism. By partnering with the retinoid X receptor (RXR), FXR influences gene transcription critical to these metabolic pathways. It also interacts with other NRs, including the pregnane X receptor (PXR), liver X receptor (LXR),
Thamer Abdulla Mohammed, Munaf H. Zalzala   +1 more
openaire   +2 more sources

Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.

European Journal of Pharmacology, 2023
Su-Te Chen, Shangwen Sun, Ya-nan Feng, Xiuqun Li, Guoliang Yin, Pengpeng Liang, Wenfei Yu, Decheng Meng, Xin Zhang, Hongshuai Liu, Fengxia Zhang   +10 more
semanticscholar   +1 more source

How Sweet It Is To Activate FXR

Hepatology, 2014
Jansen, Peter L. M., Schaap, Frank G.
openaire   +4 more sources

Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

Cell Metabolism, 2021
Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang   +2 more
exaly  

FXR

2002
Vincent Laudet, Hinrich Gronemeyer
openaire   +1 more source

Fxr

2010
Yandong Wang, Weidong Chen, Xiaosong Chen, Wendong Huang   +3 more
openaire   +1 more source