Results 181 to 190 of about 103,546 (246)

AI-driven rational design of promiscuous and selective plastic-binding peptides. [PDF]

Chem Sci
Jain V, Bergman MT, Hall CK, You F.
europepmc   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Lower social participation and physical activity in patients with craniopharyngioma or CNS germ cell tumor: Their association with apathy. [PDF]

PCN Rep
Komaki M, Arakawa Y, Ueda K, Umeda K, Ueno T, Tanji M, Mineharu Y, Funaki T, Kikuchi T, Murai T, Tabata A.   +10 more
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Solid-solution surface alloying of Cu nanocubes with platinum-group metals: pathway switching and catalyst stabilization in CO₂ reduction. [PDF]

Chem Sci
Kobayashi H, Hikino S, Anzai A, Matsuu T, Umeno M, Noguchi TG, Donoshita M, Yamamoto T, Murakami Y, Kato K, Sugiyama T, Setoyama H, Shirasawa T, Shimohata Y, Ishimoto T, Yamauchi M.   +15 more
europepmc   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

A Selective-Transport Elastomeric Coating Regulating Hierarchical Solid Electrolyte Interphase for Low-Temperature Lithium-Metal Batteries. [PDF]

Adv Mater
Ding H, Bai L, Shan X, Li Y, Jin S, Qin H, Gao J, Gou J, Tian M, Cao PF.   +9 more
europepmc   +1 more source

Aβ1‐40 induces venular endothelial cell ferroptosis in cerebral amyloid angiopathy via the ATF3/xCT axis: Insights from single‐cell RNA sequencing

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Amyloid‐beta (Aβ)‐induced microvascular injury is a key pathological feature of cerebral amyloid angiopathy (CAA). Recent evidence suggests that ferroptosis is implicated in Aβ pathology; however, its cell‐type specificity and regulatory mechanisms within the cerebral microvasculature in CAA remain unclear. METHODS Single‐cell RNA
Chunmei Wu, Xiaodong Ye, Hualin Chen, Yongkang Fang, Yan Lan, Jiahe Ye, Xin Liu, Ruizhi Xiao, Suiqiang Zhu, Shanshan Huang   +9 more
wiley   +1 more source

Non-Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis. [PDF]

Angew Chem Int Ed Engl
Wang FY, Prescimone A, Häussinger D, Tiefenbacher K.   +3 more
europepmc   +1 more source

A Boric Acid‐SnO2 Composite for Interfacial Stabilization of Highly Efficient Perovskite Solar Cells

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
The interaction between BA and FAI can inhibit the oxidation of iodide ions to elemental iodine (I2) in perovskite films, significantly improving the films' UV stability, and the power conversion efficiency (PCE) of the device containing BA reaches 25.7%.
Kun Gao, Yingping Fan, Dachang Liu, Qiangqiang Zhao, Bingqian Zhang, Nannan Gao, Han Liu, Xiao Wang, Caixia Wang, Wei Li, Jingfu Jiang, Shuping Pang, Li Wang   +12 more
wiley   +1 more source