Results 131 to 140 of about 5,676,437 (287)

Strengthening enterprise competitiveness by synchronizing supply chain

open access: yesBusiness: Theory and Practice, 2011
When competition is fierce and many producers try to create a competitive advantage by lowering prices, price wars are very common, but only few survive. Low prices erode producers’ margins and economic viability of the company. Low prices are very short-
Rimvydas Jasinavičius   +1 more
doaj  

Food, Financial Crises, and Complex Derivatives: A Tale of High Stakes Innovation and Diversification [PDF]

open access: yes
The 2008 food price crisis was an integral part of the financial crisis. In fact, the food price crisis was the second crisis in a chain of events that began in 2007 with the mortgage crisis, and culminated in the worst financial crisis since the Great ...
Songwe, Vera
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Cumbre del G-20: ¿y después de Toronto? [PDF]

open access: yes, 2010
¿Qué ha supuesto la cumbre del G-20 de Toronto para la agenda de problemas de la economía global? El Marco para un Crecimiento sólido y equilibrado planteado en la cumbre del G-20 en Pittsburgh –que requería más ahorro y exportaciones para los países ...
Tugores Ques, Juan
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Fresh Look at Global Governance: Exploring Objective Criteria for Representation [PDF]

open access: yes
The geopolitical world of the 21st century is very different than that of the post– World War II era. In this new world order, what constitutes a system of global governance?
Enrique Rueda-Sabater   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Problems of public sector accounting and financial reporting standards implementation into practice

open access: yesBusiness: Theory and Practice, 2011
This article analyzes process of realization in practice and problems faced by accountants in implementation of Accounting and Financial Statement System Reform in the Public Sector which currently takes place in the  European Union and other developed ...
Jovita Bikienė
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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