Results 131 to 140 of about 23,382,965 (280)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Warren G. Harding letter to Mary E. Lee, January 20, 1920
, 1920 In this letter dated January 20, 1920, Senator Warren G. Harding writes to Mary E. Lee of Westerville, Ohio, in response to her letter of January 12.
Harding, Warren G. (Warren Gamaliel), 1865-1923
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Warren G. Harding letter to John R. Shillady, February 20, 1920
, 1920 In this letter dated February 20, 1920, Senator Warren G. Harding writes to John R. Shillady of New York in response to his letter of February 18. Harding states that he supports the advancement of African Americans, and claims that the Republican Party ...
Harding, Warren G. (Warren Gamaliel), 1865-1923
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Warren G. Harding letter to Nahum D. Brascher, September 20, 1919
, 1919 In this letter dated September 20, 1919, Senator Warren G. Harding writes to Nahum D. Brascher, editor in chief of the Associated Negro Press, in response to his letter of September 12, 1919, in which he emphasizes the increased circulation of African ...
Harding, Warren G. (Warren Gamaliel), 1865-1923
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Napoli, Biblioteca Nazionale «Vittorio Emanuele III», S.Q. XIII G 20
Scheda catalografica dell'incunabolo con segnatura S.Q.
Martina Caronte
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source