Results 31 to 40 of about 276,085 (274)

Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. [PDF]

PLoS ONE, 2013
Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver by both reducing hepatic BA toxicity and increasing their ...
Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Piotr Milkiewicz, Olivier Barbier   +6 more
doaj   +1 more source

Full counting statistics of the subsystem energy in the free fermions and the quantum spin chains

, 2017
We calculate the full counting statistics (FCS) of a subsystem energy in free fermionic systems by means of the Grassmann variables. We demonstrate that the generating function of these systems can be written as a determinant formula with respect to the ...
Najafi, Khadijeh, Rajabpour, M. A.
core   +1 more source

$S^1$-equivariant Rabinowitz-Floer homology [PDF]

, 2016
We define the $S^1$-equivariant Rabinowitz-Floer homology of a bounding contact hypersurface $\Sigma$ in an exact symplectic manifold, and show by a geometric argument that it vanishes if $\Sigma$ is displaceable.
Frauenfelder, Urs, Schlenk, Felix
core   +2 more sources

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Canadian Journal of Gastroenterology and Hepatology, 2018
Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography coupled
Martin Perreault, Ewa Wunsch, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Guy G. Poirier, Piotr Milkiewicz, Olivier Barbier   +8 more
doaj   +1 more source

Assessing the Reliability of Planktic Foraminifera Ba/Ca as a Proxy for Salinity off the Sunda Strait

Ilmu Kelautan, 2017
The Ba/Ca ratio of planktic foraminifera carbonate serves as a new geochemical proxy for seawater Ba/Ca and thus providing information on modern and past salinity and freshwater discharge.
Riza Yuliratno Setiawan, Anindya Wirasatriya, Hasrizal Bin Shaari, Eko Setyobudi, Faizal Rachman   +4 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Nicht belegter Zusatznutzen durch späte Änderungen der zweckmäßigen Vergleichstherapie

Monitor Versorgungsforschung
Im Rahmen der frühen Nutzenbewertung werden neue unterlagengeschützte Arzneimittel auf den Zusatznutzen im Vergleich zur zweckmäßigen Vergleichstherapie (zVT) bewertet.
Antonio Enrique Grau Morenilla MSc, Jan Laufenberg MSc, Dr. PH Andrej Rasch, Dr. rer. nat. Arne Bartol   +3 more
doaj   +1 more source

Divergence terms in the supertrace heat asymptotics for the de Rham complex on a manifold with boundary

, 2003
We use invariance theory to determine the coefficient $a_{m+1,m}^{d+\delta}$ in the supertrace for the twisted de Rham complex with absolute boundary conditions.Comment: 19 pages, LaTeX, Theorem 1.2 ...
Branson, Chern, Chern, Chern, D. Vassilevich, Gilkey, Greiner, K. Kirsten, McKean, P. Gilkey, Patodi, Seeley, Witten   +12 more
core   +1 more source