Results 31 to 40 of about 263,600 (280)

Nicht belegter Zusatznutzen durch späte Änderungen der zweckmäßigen Vergleichstherapie

Monitor Versorgungsforschung
Im Rahmen der frühen Nutzenbewertung werden neue unterlagengeschützte Arzneimittel auf den Zusatznutzen im Vergleich zur zweckmäßigen Vergleichstherapie (zVT) bewertet.
Antonio Enrique Grau Morenilla MSc, Jan Laufenberg MSc, Dr. PH Andrej Rasch, Dr. rer. nat. Arne Bartol   +3 more
doaj   +1 more source

Assessing the Reliability of Planktic Foraminifera Ba/Ca as a Proxy for Salinity off the Sunda Strait

Ilmu Kelautan, 2017
The Ba/Ca ratio of planktic foraminifera carbonate serves as a new geochemical proxy for seawater Ba/Ca and thus providing information on modern and past salinity and freshwater discharge.
Riza Yuliratno Setiawan, Anindya Wirasatriya, Hasrizal Bin Shaari, Eko Setyobudi, Faizal Rachman   +4 more
doaj   +1 more source

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt, Elisabeth T. Tracy, Anghela Paredes, Catherine Beckhorn, Harold J. Leraas, Joseph Fusco, Katlyn G. McKay, Nelly‐Ange T. Kontchou, Zachary J. Kastenberg, David W. Hoyt, Jonathan Roach, Emily K. Myers, Nicholas G. Cost, Bhargava Mullapudi, Charles R. Marchese, Amanda R. Jensen, Timothy B. Lautz, Michela Carter, Roshni Dasgupta, John Lundstedt, Joseph G. Brungardt, Lindsay Talbot, Andrew M. Davidoff, Andrew J. Murphy, Jennifer H. Aldrink, Sara Mansfield, Nelson Piche, Annie Le‐Nguyen, Dave R. Lal, Brian T. Craig, Jennifer M. Schuh, Barrett P. Cromeens, Sindhu Mannava, Shannon Castle, Adriana Lopez, Kelsey Mello, Joshua Short, Robin T. Petroze, Shay Rajaval, Grace R. Thompson, Peter Mattei, David H. Rothstein, Elizabeth Fialkowski, Kathryn Fowler, Nathan Martchenke, Barrie S. Rich, Richard D. Glick, Erin G. Brown, Kathleen Doyle, Paige Abril, Natashia Seemann, Jacob Davidson, Claire A. Wilson, Hau D. Le, Devashish Joshi, Michael Stellon, Tamer Ahmed, Alexandra Dimmer, Peter F. Ehrlich, Maya Hammoud, Keyonna Williams, Christa N. Grant, Merit Gorgy, Stephanie F. Polites, Julia Debertin, Danielle B. Cameron, Alyssa Stetson, Eugene S. Kim, William G. Lee, Aaron Barkhordar, Mary Austin, Brian A. Coakley, Anastasia Kahan, Joseph T. Murphy, Michael Pitonak, Chloé Boehmer, Marcus M. Malek   +76 more
wiley   +1 more source

ASV Multiple Sklerose aus Patientensicht – ein Fallbeispiel

Monitor Versorgungsforschung
Die Ambulante spezialfachärztliche Versorgung (ASV) soll Menschen mit seltenen Erkrankungen oder mit besonderen Krankheitsverläufen eine strukturierte, sektoren-übergreifende Versorgung gewährleisten. Eine entsprechende Rechtsgrundlage ist in § 116b Abs.
Dr. PH Patrick Ziech
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Das Verfahren der anwendungsbegleitenden Datenerhebung für die frühe Nutzenbewertung

Monitor Versorgungsforschung
Am 16. August 2019 trat das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft. Es wurden Änderungen in § 35a SGB V vorgenommen, die es dem Gemeinsamen Bundesausschuss (G-BA) ermöglichen, bei Arzneimitteln zur Behandlung eines ...
Dr. rer. nat. Florian Jantschak, Dr. med. Katharina Wenzel-Seifert, Dr. rer. nat. Tilman Broicher, Dr. med. Maike Schier   +3 more
doaj   +1 more source

Tumour necrosis factor-alpha gene polymorphisms in Iranian patients with biliary atresia

African Journal of Paediatric Surgery, 2014
Background: Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts. This study evaluated the relationship between single-nucleotide polymorphisms in the promoter region of tumour necrosis factor-alpha (TNF-α) gene and ...
Nikou Fotouhi, Morteza Bonyadi, Zohreh Jahanafrooz, Nahid Ahmadian, Mahnaz Sadeghi-Shabestari, Saeid Aslanabadi, Robabeh Ghergherehchi, Milad Pormosavi, Mandana Rafeey   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Content of interleukins-4, 6 and nuclear transcription factor NF-κB in children with atopic bronchial asthma depending on Ile50Val polymorphism of IL4RA gene, severity of the disease course and level of its control

Zaporožskij Medicinskij Žurnal, 2019
Many studies on polymorphic variants of cytokines genes indicate that their role in bronchial asthma development in children is still not fully understood. Aim.
V. M. Dudnyk, L. V. Moroz, N. V. Zaichko, O. V. Kutsak   +3 more
doaj   +1 more source

Preparation and molten salts corrosion behavior of high-entropy (Ca,Sr,Ba)TMO3 (TM= Zr, Hf and Ta): Promising protecting materials of reference electrode for metal smelting through fused salts electrolysis

Corrosion Communications, 2021
The protecting materials of reference electrode with good corrosion resistance to molten salts play vital roles in realizing smelting of refractory and rare earth metals through fused salts electrolysis.
Shuaihang Qiu, Huimin Xiang, Fu-Zhi Dai, Hailong Wang, Yanchun Zhou   +4 more
doaj   +1 more source