Results 51 to 60 of about 859,407 (298)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Investigating 3 Axis CNC Processes for Creating 3D Objects [PDF]

, 2012
Using 3 axis CNC (computer numerical code) routing processes of the Visualization Lab, the CNC was tested for 3D object milling. The CNC process was designed for manufacturing 2D cut out objects with or without a 3D surface.
Newsum, Michael Jake
core   +1 more source

3D hybrid wound devices for spatiotemporally controlled release kinetics [PDF]

, 2012
This paper presents localized and temporal control of releasekinetics over 3-dimensional (3D) hybridwounddevices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D.
Koc, Bahattin, Koç, Bahattin, Ozbolat, Ibrahim T., Özbolat, İbrahim T.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Dose-response assessment of dipentyl phthalate effects on testosterone production and morphogenesis of late-gestation fetal rat testis

Environment International
Dipentyl phthalate (DPeP) is a potent male reproductive toxicant that reduces fetal testicular testosterone production and induces abnormal fetal testis morphology, including multinucleated germ cells (MNGs).
Maansi V. Gupta, Justin M. Conley, Christy Lambright, Logan F. Chin, Susan J. Hall, L. Earl Gray, Daniel J. Spade   +6 more
doaj   +1 more source

Development of an Automatic Robotic Procedure for Machining of Skull Prosthesis

Robotics, 2020
The project presented in this paper develops within the field of automation in the medical-surgical sector. It aims at automating the process for the realization of prosthetic devices for the skull in cranioplasty, following a craniotomy intervention for
Kevin Castelli, Marco Carnevale, Hermes Giberti   +2 more
doaj   +1 more source

EGCL: an extended G-Code Language with flow control, functions and mnemonic variables [PDF]

, 2016
In the context of computer numerical control (CNC) and computer aided manufacturing (CAM), the capabilities of programming languages such as symbolic and intuitive programming, program portability and geometrical portfolio have special importance -- They
Arroyave, S., Cardona, J.F., Ruíz, Óscar E.   +2 more
core  

Flexible right sized honing technology for fast engine finishing [PDF]

, 2013
The paper discusses a flexible honing technology by describing the new prototype machine with its specificity. Three original methods produced by the flexible honing prototype have been studied.
DUMUR, Didier, EL MANSORI, Mohamed, FRABOLOT, Marc, GOELDEL, Benoit, VOISIN, Julien   +4 more
core   +5 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural Elucidation, DFT Calculations, Hirshfeld Surface Analysis, Molecular Dynamics Simulation, ADMET Profiles, and Molecular Docking of Two Benzazocine Derivatives NAOP-12 and NEMKH-12

Orbital: The Electronic Journal of Chemistry
In this study two novel benzazocine derivatives containing potentially anticancer properties, (a) NAOP-12 (C24H16N4) & (b) NEMKH-12 (C25H18N4), were investigated utilizing quantum computational technique. The equilibrium geometries of the compounds have
Tanveer Hasan, Raza Murad Ghalib, Sayed Hasan Mehdi, Tazeem, Nazia Kazmi   +4 more
doaj   +1 more source