Results 71 to 80 of about 1,153,523 (263)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Advanced monolayer and layer-by-layer nanocapsule systems for sustained release of carvacrol and trans-cinnamaldehyde against multidrug-resistant Salmonella in poultry

Applied Microbiology and Biotechnology
The rise of antibiotic-resistant Salmonella in poultry poses a significant public health challenge. This study assessed the efficacy of carvacrol and trans-cinnamaldehyde, in free and nanoencapsulated forms, as natural alternatives to chlorine for ...
Samah Mechmechani, Kosar Zadeh, Neda Zadeh, Adem Gharsallaoui, Nahla O. Eltai, Tareq M. Osaili, Layal Karam   +6 more
doaj   +1 more source

Controlled synthesis of solvent-responsive continuous bidirectional deformation natural rubber composite films based on nano-g-C3N4 modification and epoxy natural rubber double-layer composite

Industrial Crops and Products
Stimuli-responsive elastomeric materials, capable of controllably and reversibly changing under external stimuli, are the key materials of intellectualized and automatic system with immense transformative application potentiality.
Bangsen Li, Yan Zhang, Xiaoxue Lin, Huaide Qin, Jianjun Shi, Zaifeng Shi   +5 more
doaj   +1 more source

Computing Minimal Doubly Resolving Sets and the Strong Metric Dimension of the Layer Sun Graph and the Line Graph of the Layer Sun Graph

Complexity, 2020
Let G be a finite, connected graph of order of, at least, 2 with vertex set VG and edge set EG. A set S of vertices of the graph G is a doubly resolving set for G if every two distinct vertices of G are doubly resolved by some two vertices of S.
Jia-Bao Liu, Ali Zafari
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Deep CNNs with Robust LBP Guiding Pooling for Face Recognition

Sensors, 2018
Pooling layer in Convolutional Neural Networks (CNNs) is designed to reduce dimensions and computational complexity. Unfortunately, CNN is easily disturbed by noise in images when extracting features from input images.
Zhongjian Ma, Yuanyuan Ding, Baoqing Li, Xiaobing Yuan   +3 more
doaj   +1 more source

Crystal chemistry characteristics and dispersion performance of Ca-montmorillonite with different layer charge density

Materials Research Express, 2020
The correlation between crystal chemistry characteristics and dispersion performance of Ca-montmorillonite with different layer charge density was studied. The four kinds of purified montmorillonite were characterized by XRD, XRF, FTIR, SEM, TEM, BET, TG-
Jun Qiu, Shan Jiang, Yueting Wang, Guowei Chen, Dongliang Liu, Xiaodong Liu, Guifang Wang, Peng Wu, Xianjun Lyu   +8 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Influence of different systems of grazing, type of swards and fertilizing on underground phytomass of pastures

Plant, Soil and Environment, 2003
Problems concerning total dry weight and distribution of underground phytomass were studied in a pasture trial at Rapotin near Šumperk, the CzechRepublicin the period 1995-1999.
S. Hejduk, F. Hrabě
doaj   +1 more source