Results 121 to 130 of about 16,590,082 (290)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Loop groups in Yang–Mills theory

Physics Letters B, 2015
We consider the Yang–Mills equations with a matrix gauge group G on the de Sitter dS4, anti-de Sitter AdS4 and Minkowski R3,1 spaces. On all these spaces one can introduce a doubly warped metric in the form ds2=−du2+f2dv2+h2dsH22, where f and h are the ...
Alexander D. Popov
doaj   +1 more source

A unification of \(G\)-metric, partial metric, and \(b\)-metric spaces

Abstract and Applied Analysis, 2013
Summary: Using the concepts of \(G\)-metric, partial metric, and \(b\)-metric spaces, we define a new concept of generalized partial \(b\)-metric space. Topological and structural properties of the new space are investigated and certain fixed point theorems for contractive mappings in such spaces are obtained.
Hussain, Nawab, Rezaei Roshan, Jamal, Parvaneh, Vahid, Latif, Abdul   +3 more
openaire   +3 more sources

Fixed point results on complete G-metric spaces

, 2011
In this paper several fixed point theorems for a class of mappings defined on a complete G-metric space are proved. In the same time we show that if the G-metric space (X, G) is symmetric then the existence and uniqueness of these fixed point results ...
Mona Khandagji, Zead Mustafa, Wasfi Shatanawi   +2 more
core   +1 more source

Group representations in indefinite metric spaces [PDF]

, 1984
A group G of symmetry transformations of the rays of an indefinite metric space V with metric operator eta leads to a projective representation U of G in V in terms of eta-unitary, eta-antiunitary, eta-pseudounitary, and eta-pseudoantiunitary operators ...
P. M. van den Broek, van den Broek, P.M.
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Generalized Banach contraction mapping principle in generalized metric spaces with a ternary relation [PDF]

Surveys in Mathematics and its Applications, 2019
In the present work the use of ternary relations is introduced in fixed point theory to obtain some fixed point results in G-metric spaces. Amongst several generalizations of metric spaces suggested in recent times, G-metric spaces are the ones in which ...
Y. U. Gaba, C. A. Agyingi, Binayak S. Choudhury, P. Maity   +3 more
doaj  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source