Results 101 to 110 of about 13,970,863 (343)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Twisted $\\mathcal{D}$-module extensions of local systems on a certain\n subvariety isomorphic to ${\\mathbb{G}_{\\text{m}}}^2$ of the affine flag\n variety of $\\text{SL}_2$ [PDF]
, 2020 Claude Eicher
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The third cohomology group classifies crossed module extensions
, 2009 We give an elementary proof of the well-known fact that the third cohomology group H^3(G, M) of a group G with coefficients in an abelian G-module M is in bijection to the set Ext^2(G, M) of equivalence classes of crossed module extensions of G with M ...
Thomas, Sebastian
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Methylene Blue Degradation Using Non-Thermal Plasma
PlasmaMethylene blue (C16H18ClN3) dye can be decomposed using non-thermal plasma. However, there is a problem in that the maintenance of electrodes and dielectrics is necessary due to the durability and heat generation problems due to the high temperatures ...
Hae Kwang Kim +2 more
doaj +1 more source
Modules over group rings of groups with restrictions on the system of all proper subgroups [PDF]
International Journal of Group Theory, 2015 We consider the class M of R{modules where R is an associative ring. Let A be a module over a group ring RG, G be a group and let L(G) be the set of all proper subgroups of G. We suppose that if H 2 L(G) then A=CA(H) belongs to M. We study an RG{module A
Olga Dashkova
doaj
弱离散Koszul模(Weakly discrete Koszul modules)
Zhejiang Daxue xuebao. Lixue ban, 2014 The discrete Koszulity of finitely generated graded modules is discussed over a discrede Koszul algebra and the notion of weakly discrete Koszul module is introduced.
PANYuan(潘媛)
doaj +1 more source
On Singular Localization of $\mathfrak{g}$-modules
, 2010 We prove a singular version of Beilinson-Bernstein localization for a complex semi-simple Lie algebra following ideas from the positive characteristic case done by \cite{BMR2}. We apply this theory to translation functors, singular blocks in the Bernstein-Gelfand-Gelfand category $\BGGcat$ and Whittaker modules.
Backelin, E, Kremnizer, K
openaire +3 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source