Results 111 to 120 of about 13,968,203 (346)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

On Projective Fuzzy G –Modules

open access: yesIMPACT JOURNAL OF SCIENCE AND TECHNOLOGY, 2021
Souriar Sebastian, Thampy Abraham
openaire   +1 more source

The quasi-Zariski topology-graph on the maximal spectrum of modules over commutative rings

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2018
Let M be a module over a commutative ring and let Max(M) be the collection of all maximal submodules of M. We topologize Max(M) with quasi-Zariski topology, where M is a Max-top module. For a subset T of Max(M), we introduce a new graph G(τT*m)$G(\tau_T^{
Ansari-Toroghy H., Habibi Sh.
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Some Properties of Controlled K-g-Frames in Hilbert C∗-Modules

open access: gold, 2022
Rachid Echarghaoui   +3 more
openalex   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Module amenability for Banach modules

open access: yesCubo, 2011
We study the module amenability of Banach modules. This is a natural generalization of Johnson’s amenability of Banach algebras. As an example we show that for a discrete abelian group G, l p(G) is amenable as an l¹(G)-module if and only if G is amenable,
D Ebrahimi Bagha, M Amini
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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