Results 131 to 140 of about 13,968,203 (346)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Torsion representations arising from $(\varphi,\hat{G})$-modules
, 2012 The notion of a $(\varphi,\hat{G})$-module is defined by Tong Liu in 2010 to classify lattices in semi-stable representations. In this paper, we study torsion $(\varphi,\hat{G})$-modules, and torsion p-adic representations associated with them, including the case where p=2. First we prove that the category of torsion p-adic representations arising from
openaire +2 more sources
Tensor product for g-fusion frame in hilbert $C^{\ast}-$modules
, 2023 Fakhr-dine Nhari +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
On the structure of artinian-by-(finite rank) modules over generalized soluble groups
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Matematika, 2014 Let R be a ring and G a group. An R-module A is said to be artinian-by-(finite rank), if $\mathrm{Tor}_R(A)$ is artinian and $A/\mathrm{Tor}_R(A)$ has finite R-rank.
V.A. Chupordia
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Dimension formulas of the highest weight exceptional Lie algebra-modules
AIMS MathematicsGiven a complex simple exceptional Lie algebra $ \mathfrak g $, let $ \mathscr V_\lambda $ be an irreducible finite-dimensional $ \mathfrak g $-module with highest weight $ \lambda $.
Yupei Zhang, Yongzhi Luan
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source