Results 131 to 140 of about 16,949 (276)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Topological Amenability [PDF]

open access: yesarXiv, 2011
Let G be a locally compact topological group and X a compact space with continuous G-action. The main result of this essay states that the following statements are equivalent : 1) The action of G on X is topologically amenable ; 2) Every dual (G, X)-module of type C is a relatively injective Banach G-module ; 3) There is a G-invariant element in the ...
arxiv  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Purity and almost strict purity of Anderson $t$-modules

open access: yesComptes Rendus. Mathématique
We study the relations between the notion of purity of a $t$-module introduced by Anderson and that of almost strict purity for a $t$-module introduced by Namoijam and Papanikolas (concept already mentioned by G. Anderson and D. Goss).
Alexis, Lucas
doaj   +1 more source

Support Varieties for Frobenius Kernels of Classical Groups [PDF]

open access: yesarXiv, 2012
Let G be a simple classical algebraic group over an algebraically closed field of positive characteristic. We describe the support variety of a simple G-module over the r-th Frobenius kernel of G, in terms of its calculation over the first Frobenius kernel. We then use this result to compute the block varieties of the Frobenius kernels of G.
arxiv  

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

open access: yesFEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei   +6 more
wiley   +1 more source

Architected Lattices with a Topological Transition

open access: yesAdvanced Engineering Materials, EarlyView., 2023
This article develops topological metamaterials showing multidirectional two‐step deformation under compression by embedding contact‐enabled topological mechanisms into lattice structures. Experiments on 3D‐printed 2D and 3D lattices and finite element simulations are conducted to demonstrate the working principle of the topological metamaterials.
Shivam Agarwal, Lihua Jin
wiley   +1 more source

On graded n−absorbing submodules

open access: yesLe Matematiche, 2015
Let G be a group with identity e. Let R be a G−graded commutative ring, M be a graded R−module and n be a positive integer. In this article, we introduce and study the concepts of graded n−absorbing submodules.
Mohammad Hamoda, Arwa Eid Ashour
doaj  

Correction to “ Water isotope module of the ECHAM atmospheric general circulation model: A study on timescales from days to several years” by G. Hoffmann et al. [PDF]

open access: bronze, 1998
Jingmin Li   +7 more
openalex   +1 more source

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