Results 181 to 190 of about 13,968,203 (346)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

CAMP: a modular metagenomics analysis system for integrated multistep data exploration. [PDF]

NAR Genom Bioinform
Mak L, Tierney B, Wei W, Ronkowski C, Toscan RB, Turhan B, Toomey M, Andrade-Martínez JS, Fu C, Lucaci AG, Solano AHB, Setubal JC, Henriksen JR, Zimmerman S, Kopbayeva M, Noyvert A, Iwan Z, Kar S, Nakazawa N, Meleshko D, Horyslavets D, Kantsypa V, Frolova A, Kahles A, Danko D, Elhaik E, Labaj P, Mangul S, International MetaSUB Consortium , Mason CE, Hajirasouliha I.   +30 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

An Automatic Detection Model for Low-Contrast Discrete Defects on Aluminum Alloy Wheels. [PDF]

Sensors (Basel)
Yang J, Chen P, Wang M.
europepmc   +1 more source

Restrictions to G(𝔽_p) and G_(r) of rational G-modules [PDF]

, 2011
Eric M. Friedlander
openalex   +1 more source

Weak amenability of module extensions of banach algebras

, 2002
Y. Zhang
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation. [PDF]

J Neurochem
Wehle DT, Brown EA, Stamenkovic V, Gniffen B, Harsh FM, Smith SEP.   +5 more
europepmc   +1 more source

Controlled g-frames and their dual in Hilbert $C^{\ast}-$modules

, 2023
Abdelilah Karara, Mohamed Rossafi, Samir Kabbaj   +2 more
openalex   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source