Results 81 to 90 of about 16,949 (276)

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Frames in super Hilbert modules [PDF]

Sahand Communications in Mathematical Analysis, 2018
In this paper, we define super Hilbert module and investigate frames in this space. Super Hilbert modules are  generalization of super Hilbert spaces in Hilbert C*-module setting.
Mehdi Rashidi-Kouchi
doaj  

Group representations on Riemann-Roch spaces of some Hurwitz curves [PDF]

arXiv, 2006
Let q>1 denote an integer relatively prime to 2,3,7 and for which G=PSL(2,q) is a Hurwitz group for a smooth projective curve X defined over C. We compute the G-module structure of the Riemann-Roch space L(D), where D is an invariant divisor on X of positive degree. This depends on a computation of the ramification module, which we give explicitly.
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

The category of generalized crossed modules [PDF]

Categories and General Algebraic Structures with Applications, 2019
In the definition of a crossed module $(T,G,rho)$, the actions of the group $T$ and $G$ on themselves are given by conjugation. In this paper, we consider these actions to be arbitrary and thus generalize the concept of ordinary crossed module. Therefore,
Mahdieh Yavari, Alireza Salemkar
doaj  

Novel Integration of CAPP in a G-Code Generation Module Using Macro Programming for CNC Application

Machines, 2020
In the modern manufacturing industry, the role of computer-aided process planning (CAPP) is becoming increasingly crucial. Through the application of new technologies, experience, and intelligence, CAPP is contributing to the automation of manufacturing ...
Trung Kien Nguyen, Lan Xuan Phung, Ngoc-Tam Bui   +2 more
doaj   +1 more source

A representation-valued relative Riemann-Hurwitz theorem and the Hurwitz-Hodge bundle [PDF]

arXiv, 2008
We provide a formula describing the G-module structure of the Hurwitz-Hodge bundle for admissible G-covers in terms of the Hodge bundle of the base curve, and more generally, for describing the G-module structure of the push-forward to the base of any sheaf on a family of admissible G-covers.
arxiv  

Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders [PDF]

Translational Psychiatry, 2019
AbstractMelanocortin 4 receptor (MC4R) plays a key role in regulation of appetite activated by its main ligand α-melanocyte-stimulating hormone (α-MSH) in both central and peripheral targets. α-MSH also binds to circulating immunoglobulins (Igs) but the functional significance of such immune complexes (ICs) in MC4R signaling in normal and pathological ...
Sergueï O. Fetissov, Sergueï O. Fetissov, Jaanus Harro, Christine Bole-Feysot, Christine Bole-Feysot, Jonathan Breton, Jonathan Breton, Pierre Déchelotte, Pierre Déchelotte, Romain Legrand, Romain Legrand, Nicolas Lucas, Kirsti Akkermann, Anu Järv, Moïse Coëffier, Moïse Coëffier   +15 more
openaire   +4 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

The intersection graph of graded submodules of a graded module

Open Mathematics, 2022
In this article, we introduce and study the intersection graph of graded submodules of a graded module. Let MM be a left GG-graded RR-module. We define the intersection graph of GG-graded RR-submodules of MM, denoted by Γ(G,R,M)\Gamma \left(G,R,M), to be
Alraqad Tariq
doaj   +1 more source