Results 81 to 90 of about 13,968,203 (346)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

The category of generalized crossed modules [PDF]

open access: yesCategories and General Algebraic Structures with Applications, 2019
In the definition of a crossed module $(T,G,rho)$, the actions of the group $T$ and $G$ on themselves are given by conjugation. In this paper, we consider these actions to be arbitrary and thus generalize the concept of ordinary crossed module. Therefore,
Mahdieh Yavari, Alireza Salemkar
doaj  

The homotopy orbit spectrum for profinite groups

open access: yes, 2006
Let G be a profinite group. We define an S[[G]]-module to be a G-spectrum X that satisfies certain conditions, and, given an S[[G]]-module X, we define the homotopy orbit spectrum X_{hG}.
Davis, Daniel G.
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Tensor products and multipliers of L1(G)-modules

open access: yesIndagationes Mathematicae (Proceedings), 1976
AbstractIn [7] Rieffel is concerned with a locally compact group G and the problem of finding a concrete representation of Lp(G) ⊗L Lq(G), the tensor product of the L1(G)-modules Lp(G) and Lq(G). He shows that under some conditions Lp(G) ⊗L Lq(G) is isometrically isomorphic to a function space called Apq(G). Motivated by a theorem of Gaudry ([1]; Ch. V,
openaire   +2 more sources

Exactness Of Commutative (Implicative) Soft G-Modules

open access: yes, 2018
In this paper, we obtain some characterizations for soft sub modules of modules with respect to image, pre image and upper a-inclusion.
N. Rajakumari, J. Arun Micheal
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Filtrations of B-modules

open access: yesDuke Mathematical Journal, 1989
Let G be a semisimple, simply connected algebraic group over a field k, and let B be a Borel subgroup. The motivation of this paper is the study of tensor products of G-modules. For a dominant weight \(\lambda\), let L(\(\lambda\)) denote the associated Weyl module.
openaire   +2 more sources

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