Results 171 to 180 of about 11,933,284 (289)

Manifesto, Turkey as model and a debate on ritual slaughtering - highlights of the Dutch debate first quarter 2011 / European Stability Initiative [PDF]

, 2011
unknown
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Stability and inflation. / [PDF]

Chichester, New York, Brisbane ; John Wiley ...
Stability
core  

Stability of the Na+ Form of the Human Telomeric G‑Quadruplex: Role of Adenines in Stabilizing G‑Quadruplex Structure

ACS Omega, 2018
Brenna A. Tucker, Jason S. Hudson, Lei Ding, Edwin Lewis, Richard D. Sheardy, Eugenia Kharlampieva, David Graves   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A multi-model genotype × environment interaction analysis discerning phenotypic plasticity of the strong culm trait in rice. [PDF]

Front Plant Sci
Mamidi A, Lavuri K, Badri J, Prasad SVS, Sundaram RM.   +4 more
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Radiolabeled Angiopep-2 Peptide Vector as a Preclinical Platform for Blood-Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice. [PDF]

J Pept Sci
Fotou E, Apostolopoulou A, Bika CG, Giannakopoulou M, Bajwa DE, Moussis V, Tsikaris V, Gerothanassis IP, Alexiou GA, Bouziotis P, Tzakos AG.   +10 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Chemical grafting of waste polystyrene with acrylic acid and subsequent amine functionalization to enhance polystyrene modified bitumen characteristics. [PDF]

Sci Rep
Abo-Shanab ZL, Elsharaky EA, El-Tabey AE, Ragab AA.   +3 more
europepmc   +1 more source