Results 81 to 90 of about 1,434,621 (235)

Numerical simulations of the internal shock model in magnetized relativistic jets of blazars

, 2015
The internal shocks scenario in relativistic jets is used to explain the variability of the blazar emission. Recent studies have shown that the magnetic field significantly alters the shell collision dynamics, producing a variety of spectral energy ...
Aloy, Miguel A., Mimica, Petar, Rueda-Becerril, Jesus M.   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dynamical correlation functions and the quantum Rabi model

, 2013
We study the quantum Rabi model within the framework of the analytical solution developed in Phys. Rev. Lett. 107,100401 (2011). In particular, through time-dependent correlation functions, we give a quantitative criterion for classifying two regions of ...
Braak, Daniel, Kollar, Marcus, Romero, Guillermo, Solano, Enrique, Vallone, Fabio, Wolf, F. Alexander   +5 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A two-part phase 1 study to establish and compare the safety and local tolerability of two nasal formulations of XF-73 for decolonisation of Staphylococcus aureus: A previously investigated 0.5 mg/g viscosified gel formulation versus a modified formulation

Journal of Global Antimicrobial Resistance, 2020
Objectives: Successful decolonisation of nasal Staphylococcus aureus (SA) carriage by mupirocin is limited by increasing drug resistance. This randomised, open-label, phase 1 study compared the safety and local tolerability of two nasal formulations of ...
George A. Yendewa, J. McLeod Griffiss, Michael R. Jacobs, Scott A. Fulton, Mary Ann O’Riordan, Wesley A. Gray, Howard M. Proskin, Peter Winkle, Robert A. Salata   +8 more
doaj   +1 more source

Thermal-magnetic noise measurement of spin-torque effects on ferromagnetic resonance in MgO-based magnetic tunnel junctions

, 2009
Thermal-magnetic noise at ferromagnetic resonance (T-FMR) can be used to measure magnetic perpendicular anisotropy of nanoscale magnetic tunnel junctions (MTJs). For this purpose, T-FMR measurements were conducted with an external magnetic field up to 14
J. Z. Sun, Kittel C., L. Gao, R. Moriya, S. S. P. Parkin, X. Jiang, Y. Guan   +6 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Characteristics and classification of A-type supergiants in the Small Magellanic Cloud

, 2003
We address the relationship between spectral type and physical properties for A-type supergiants in the SMC. We first construct a self-consistent classification scheme for A supergiants, employing the calcium K to H epsilon line ratio as a temperature ...
Evans, C. J., Howarth, I. D.
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Structural Heterogeneity of Biochar Modulates’ Soil Hydraulic Properties and Nutrient Migration

Agronomy
Biochar application is a well-recognized strategy to enhance agricultural soil fertility, but its structural heterogeneity leads to inconsistent outcomes in soil improvement, particularly in water and nutrient transport dynamics.
Guohui Li, Yayong Chen, Xiaopeng Chen, Beibei Zhou, Manli Duan, Hongyan Zhu, Guomin Shao   +6 more
doaj   +1 more source