Results 81 to 90 of about 16,474 (204)

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Molecular Metabolism, 2020
Objective: The objective of this study was to determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy, and appetite suppression.
Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones   +9 more
doaj   +1 more source

One Health Surveillance of Antimicrobial Resistance in the Eastern Mediterranean: The Blackchin Guitarfish as a Case Study

GeoHealth, Volume 10, Issue 4, April 2026.
Abstract Antimicrobial resistance (AMR) poses a global One Health challenge, linking human, animal, and environmental health. Marine environments and organisms are increasingly recognized as reservoirs of antimicrobial‐resistant bacteria and mobile genetic elements.
J. Lellouche, H. Di Castro, N. Maschiah, S. Paikin, M. Zvereva, D. Tchernov, A. Scheinin, E. Cohen, D. Meron   +8 more
wiley   +1 more source

The Investment Puzzle: Unveiling Behavioral Finance, Risk Perception, and Financial Literacy

ECONOMICS
Contemporary financial theory upholds the market efficiency hypothesis, asserting that stock prices inherently embody all available information. In contrast, behavioral finance theory challenges this premise by proposing that psychological and emotional ...
Almansour Bashar Yaser, Almansour Ammar Yaser, Elkrghli Sabri, Shojaei Seyed Amirhossein   +3 more
doaj   +1 more source

Correlates of Post‐Introduction Displacement in a Conservation Translocation of Threespine Stickleback

Freshwater Biology, Volume 71, Issue 4, April 2026.
ABSTRACT Predicting the distance between an individual's release point into a new environment and their subsequent location (‘displacement’) could be useful during biological ‘introduction’ events (e.g., invasions/translocations) because variation in displacement could lead to spatially‐structured ecological and evolutionary effects, as well as ...
Alexis M. Heckley, Rowan D. H. Barrett, Alison M. Bell, Daniel I. Bolnick, Francis Dinh, Lucas Eckert, Grant E. Haines, Catherine L. Peichel, Andrew P. Hendry, Kiyoko M. Gotanda   +9 more
wiley   +1 more source

Symmetries and Ambiguities in the linear sigma model with light quarks

, 2005
We investigate the role of undetermined finite contributions generated by radiative corrections in a $SU(2)\times SU(2)$ linear sigma model with quarks.
A. A. OSIPOV, A. L. MOTA, B. HILLER, Carneiro D., DeWitt B., E. W. DIAS, M. C. NEMES, M. SAMPAIO, Vaks V. G.   +8 more
core   +3 more sources

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, Volume 42, Issue 2, March/April 2026.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

G40(P) What Delays Discharge in Children with Life Limiting Conditions? A Qualitative Study of the Perceptions of Parents and Medical Professionals [PDF]

Archives of Disease in Childhood, 2013
Background It is important that any family of a child with a life limiting condition (LLC) have the option of where they would like their child to receive care (ACT 2010, DOH 2008) and do not have unnecessary protracted periods of hospital admission. Aims The aim of the project was to establish the perceptions of professionals and parents regarding ...
openaire   +1 more source

Levels and Effects of Nogo‐B in Patients With Type 2 Diabetes or Hyperglycemic HUVEC Model

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Nogo‐B levels significantly decrease in T2DM patients with or without vascular complications (VC). Nogo‐B alleviates endothelial cell injury by affecting TGF‐β signalling in an in vitro model. ABSTRACT Background There is still a lack of enough evidence about Nogo‐B levels and vascular complications in patients with type 2 diabetes.
Laurent Irakoze, Linqiang Ma, Yuanfeng Gu, Xiangjun Chen, Fanling Zeng, Rong Luo, Yulian Lai, Xun Li, Shangbin Chen, Paul Banderembako, Liliane Nkengurutse, Xun Lei, Xiaoqiu Xiao, Qingfeng Cheng   +13 more
wiley   +1 more source

Quark bilinear step scaling functions and their continuum limit extrapolation

, 2003
Some new results on nonperturbative renormalisation of quark bilinears in quenched QCD with Schroedinger Functional techniques are presented. Special emphasis is put on a study of the universality of the continuum limit for step scaling functions ...
A. Vladikas, ALPHA, ALPHA, Bhattacharya, C. Pena, Capitani, de Divitiis, Guagnelli, J. Heitger, Lüscher, Lüscher, M. Guagnelh, Mischer, Sommer   +13 more
core   +1 more source

Impact of sentimental factors on stock portfolio returns –an empirical analysis

Heliyon
This study aims to introduce an integrated model for understanding the influence of various sentimental factors in conjunction with macroeconomic factors on portfolio returns across ten industry sectors within the US market. These sentimental factors are
Rajesh Kumar, Sujit K S
doaj   +1 more source