Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands. [PDF]
Angew Chem Int Ed EnglThis study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Fullenkamp CR +8 more
europepmc +3 more sources
Reality and expectations of old-age pension savings in the pension system of the Slovak Republic
Review of Economic Perspectives, 2021 The aim of the authors is to provide a critical statistical-analytical view of the current pension system of the Slovak Republic with special regard to old -age pension savings in its fifteen-year existence, resulting in proposals for adjustments to its ...
Sika Peter, Vidová Jarmila
doaj +1 more source
Corona mortis injury causing delayed presentation of pelvic pseudoaneurysm
Radiology Case Reports, 2021 Pseudoaneurysms are rare complications in urological surgery. Typically, they would present with pain, haematuria or anaemia. We report a 60-year-old patient who was found to have a chronic pseudoaneurysm via a corona mortis vascular variant, 3 months ...
Umberto Pisano, MD, MSc, MRCS, FRCR +2 more
doaj +1 more source
MAS NMR detection of hydrogen bonds for protein secondary structure characterization [PDF]
, 2020 Hydrogen bonds are essential for protein structure and function, making experimental access to long-range interactions between amide protons and heteroatoms invaluable. Here we show that measuring distance restraints involving backbone hydrogen atoms and
Friedrich, Daniel +3 more
core +1 more source
IDOL G51S Variant Is Associated With High Blood Cholesterol and Increases Low-Density Lipoprotein Receptor Degradation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective: A high level of LDL-C (low-density lipoprotein cholesterol) is a major risk factor for cardiovascular disease. The E3 ubiquitin ligase named IDOL (inducible degrader of the LDLR [LDL receptor]; also known as MYLIP [myosin regulatory light chain interacting protein]) mediates degradation of LDLR through ubiquitinating
Dilare, Adi +13 more
openaire +2 more sources
Review of Economic Perspectives, 2020 There are many concerns about financial competences of Millennials. Initial research on this generation suggests that it is less financially knowledgeable and exhibits less healthy financial behaviours compared to other generations.
Cwynar Andrzej
doaj +1 more source
Weighing simulated galaxy clusters using lensing and X-ray [PDF]
, 2009 We aim at investigating potential biases in lensing and X-ray methods to measure the cluster mass profiles. We do so by performing realistic simulations of lensing and X-ray observations that are subsequently analyzed using observational techniques.
Bellagamba, F. +7 more
core +1 more source
“Every knock is a boost”. Cyber risk behaviour among Poles
Economics and Business Review, 2021 The purpose of this study is to evaluate the safety of individuals’ behaviour in the cyber world, especially when using financial services. The article focuses on knowledge of cybersecurity issues, cyber risk awareness and respondents’ self-assessment as
Cichowicz Ewa +2 more
doaj +1 more source
X-MAS2: Study Systematics on the ICM Metallicity Measurements [PDF]
, 2007 (Abridged)The X-ray measurements of the ICM metallicity are becoming more frequent due to the availability of powerful X-ray telescope with excellent spatial and spectral resolutions.
E. Rasia +18 more
core +1 more source
G51 Admissions to PICU in England and Wales with Refractory Convulsive Status Epilepticus: A Two-Year National Epidemiological Study [PDF]
Archives of Disease in Childhood, 2013 Aims To obtain epidemiological data on the prevalence, aetiology, management and outcome of refractory convulsive status epilepticus (RCSE). Methods Data on children admitted with RCSE to eight paediatric intensive care units (PICUs) were collected retrospectively using a standard proforma designed and co-ordinated by PICAnet.
I. Tully +6 more
openaire +1 more source