Results 51 to 60 of about 1,019,197 (220)

Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency

BMC Medicine, 2020
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. The clinical phenotype is variable and includes asymptomatic individuals, episodic hemolysis induced by oxidative stress, and chronic ...
James J. Gilchrist, Sophie Uyoga, Matti Pirinen, Anna Rautanen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, The Kenyan Bacteraemia Study Group, Adrian V. S. Hill, J. Anthony G. Scott, Thomas N. Williams   +10 more
doaj   +1 more source

G6PD deficiency and malaria selection [PDF]

Heredity, 2011
In his valuable review on genetics of malaria resistance, Hedrick (2011) tackles the interesting issue of the protection against Plasmodium falciparum afforded by G6PD deficiency. Specifically, he quotes data from a study (Ruwende et al., 1995) conducted in Gambia and in Kenya, from which it was claimed that the degree of protection was similar in ...
openaire   +2 more sources

Secondary Reporting of G6PD Deficiency on Newborn Screening

International Journal of Neonatal Screening, 2023
In April 2019, the Alberta Newborn Screening Program expanded to include screening for classic galactosemia using a two-tier screening approach. This approach secondarily identifies infants with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Stephanie C. Hoang, Pamela Blumenschein, Margaret Lilley, Larissa Olshaski, Aisha Bruce, Nicola A. M. Wright, Ross Ridsdale, Susan Christian   +7 more
doaj   +1 more source

Chinese newborn screening for the incidence of G6PD deficiency and variant of G6PD gene from 2013 to 2017

Human Mutation, 2019
Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is one of the most common X‐linked enzymopathies caused by G6PD gene variant. We aimed to provide the characteristics of G6PD deficiency and G6PD gene variant distribution in a large Chinese newborn ...
Zhidai Liu, Chao-wen Yu, Qingge Li, R. Cai, Yiping Qu, Weipeng Wang, Jie Wang, Jinwen Feng, Wenbin Zhu, M. Ou, Weitong Huang, Deguo Tang, W. Guo, Fangjie Liu, Yanhua Chen, Lifang Fu, Yanxia Zhou, Wenqiong Lv, Hang Zhang, Juan-Juan Zhang, Ming Wang, Jing Yang, Ke-xing Wan, Jing-kun Miao, Zhao-jian Yuan, Hao Liu, Xiaoyan He, Wenjie Li, Wengao Chen, Lixin Ye, Ya-jun Chen, Shuodan Huang, Haiping Liu, Hongxiang Ding, Xinhui Gan, Shuyuan Wang, R. Qiang, Minhong Gong, Ping Teng, Hua Wang, Muping Zhou, Hongwei Wei, Xiang-ju Liu, Kaijie Tang, Ya-xia Ma, Hongliang Wu, X. Shu, Yizhen Chen, Dan-yan Zhuang, Hui Li, Zhi Liu, Xiulian Liu, Yao Chen, Lidan Zhu, Xiaoyan Zhu, Caihong Mo, Hua Tang, F. Yin, Zhibing Shao, Peng-hui Zhang, Bin Peng, Qing Lu, Zhiguo Wang, L. Zou   +63 more
semanticscholar   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Co-inheritance of glucose-6-phosphate dehydrogenase deficiency mutations and hemoglobin E in a Kachin population in a malaria-endemic region of Southeast Asia.

PLoS ONE, 2017
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, β26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections.
Zeshuai Deng, Fang Yang, Yao Bai, Lijun He, Qing Li, Yanrui Wu, Lan Luo, Hong Li, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui   +11 more
doaj   +1 more source

Glucose-6-Phosphate dehydrogenase deficiency associated hemolysis in a cohort of new onset type 1 diabetes children in Guangdong province, China

Diabetology & Metabolic Syndrome, 2022
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Guangdong, China.
Aijing Xu, Minyan Jiang, Wen Zhang, Yunting Lin, Yongxian Shao, Huifen Mei, Jing Cheng, Cuili Liang, Cuiling Li, Xiuzhen Li, Li Liu   +10 more
doaj   +1 more source

Delayed Recognition of Maternal G6PD Heterozygous Status Across Prenatal and Newborn Care Interfaces

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is the most common red blood cell enzymatic disorder worldwide. Although many heterozygotes are asymptomatic, affected neonates have an increased risk for hyperbilirubinemia and related complications.
Mona M. Makhamreh, Ramiah R. Vickers, Cheryl Mensah, Wanda Dosal, Jennifer R. McKinney, April D. Adams   +5 more
wiley   +1 more source

Evaluation of the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) in a malaria endemic area in Ghana, Africa.

PLoS ONE, 2015
BackgroundGlucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that can result in red cell breakdown under oxidative stress when exposed to certain medicines including antimalarials.
Dennis Adu-Gyasi, Kwaku Poku Asante, Sam Newton, David Dosoo, Sabastina Amoako, George Adjei, Nicholas Amoako, Love Ankrah, Samuel Kofi Tchum, Emmanuel Mahama, Veronica Agyemang, Kingsley Kayan, Seth Owusu-Agyei   +12 more
doaj   +1 more source

The Impact of Glucose-6-Phosphate Dehydrogenase Deficiency on the Frequency of Vasoocclusive Crisis in Patients with Sickle Cell Anemia

Plasmatology, 2021
Background and Objectives Sickle cell anemia (SCA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency are both hereditary diseases of the red blood cells that cause hemolysis.
Hilary Nnamezie Igwilo, Lateef Salawu, Tewogbade Adeoye Adedeji   +2 more
doaj   +1 more source