Results 131 to 140 of about 5,214 (181)

Gangliosides and Cholesterol: Dual Regulators of Neuronal Membrane Framework in Autism Spectrum Disorder. [PDF]

Int J Mol Sci
Puljko B, Štracak M, Kalanj-Bognar S, Todorić Laidlaw I, Mlinac-Jerkovic K.   +4 more
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GM1-ganglioside degradation and biosynthesis in human and murine GM1-gangliosidosis

Clinica Chimica Acta, 2005
Gangliosides are building blocks of cell membranes and their biosynthesis and degradation have been extensively studied in the past. Regulation of the metabolism of these glycolipids controls fundamental cell functions. G(M1)-gangliosidosis, a neurodegenerative glycosphingolipid storage disease, is caused by deficiency of lysosomal beta-galactosidase ...
Renata, Sano, Vera M T, Trindade, Alessandra, Tessitore, Alessandra, d'Azzo, Matheus B, Vieira, Roberto, Giugliani, Janice C, Coelho   +6 more
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Ganglioside G_M1-Mediated Amyloid-beta Fibrillogenesis and Membrane Disruption

Biochemistry, 2007
There is increasing evidence that a class of cell membrane glycolipids, gangliosides, can mediate the fibrillogenesis and toxicity of Alzheimer's disease amyloid-beta peptide (Abeta). Using lipid monolayers and vesicles as model membranes, we measured the insertion of Abeta into 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-ganglioside GM1 ...
Eva Y, Chi, Shelli L, Frey, Ka Yee C, Lee   +2 more
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Preparation and Properties of Antibodies to G_D3 and G_M1 Gangliosides

Journal of Neurochemistry, 1980
Abstract: Gangliosides GD3 and GM1 were coupled to proteins by their car‐boxyl groups and antisera were raised against the complexes. Anti‐ganglioside antibodies were isolated by affinity chromatography on ganglioside‐amino‐propyl silica gel columns and the specificity of the antibodies was determined by a quantitative microcomplement fixation assay ...
S K, Kundu, D M, Marcus, R W, Veh
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Fixation and Inactivation of Cholera Toxin by G_M1Ganglioside

Scandinavian Journal of Infectious Diseases, 1973
AbstractCholera exo-enterotoxin was fixed and inactivated by pure GM1 ganglioside (Galβ1−3GalNAcβ1−4(NANβ2−3)Galβ1−4Glc-Cer) in stoichiometric proportions. This indicates that GM1 may be the tissue receptor for the toxin.
J, Holmgren, I, Lönnroth, L, Svennerholm   +2 more
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A Radioassay for G_M1 Ganglioside Concentration in Cerebrospinal Fluid

Journal of Neurochemistry, 1980
Abstract:A radioassay for the rapid determination of GM1, ganglioside concentration in small volumes of CSF from individual patients is described. The assay utilizes the high‐affinity interaction between cholera enterotoxin and GM1 ganglioside. The lower detection limit of GM1 ganglioside by this radioassay under the described incubation conditions is ...
E, Ginns, J, French
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Synthesis of a photoreactive, radiolabelled derivative of the oligosaccharide of G_M1 ganglioside

Glycobiology, 1992
A photoreactive, radioiodinatable derivative of the oligosaccharide (GM1OS) of ganglioside GM1 was synthesized as follows: GM1OS was generated from GM1 by ozonolysis and alkaline fragmentation, and reductively aminated to GM1OSNH2 (1-amino-1-deoxymonosialogangliotetraitol).
T, Pacuszka, P H, Fishman
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Preparation and Specificity of 11 Monoclonal Antibodies to G_M1 Ganglioside

Journal of Neurochemistry, 1986
Abstract Eleven monoclonal antibodies to GM1 ganglioside were prepared from hybridoma clones obtained by fusion of spleen cells from mice immunized with GM1 with mouse myeloma cells. When the reactivities of these 11 monoclonal antibodies were determined by enzyme‐linked immunosorbent assay with six glycosphingolipids (GM1, GD1a, GD1b, GT1b, GM2, and ...
S P, Mahadik, H, Laev, M M, Rapport
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