Results 91 to 100 of about 976,606 (296)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Synthesis, structural characterization, and reactivity of homocatenated Ga₄ complexes with unsaturated Ga–Ga=Ga–Ga chains

Nature Communications
The homocatenation of electron-deficient Group 13 metals to form metal-metal multiple bonds through covalent self-assembly remains extremely challenging. Herein we demonstrate the synthesis and characterizations of N-heterocyclic carbene (NHC)-stabilized digallyl digallenes (1a and 1b), which exhibit unsaturated Ga-Ga=Ga-Ga chains with trans-bent ...
Ning Zhang, Bing Wang, Yanliang Wu, Wenhao Chen, Shuxia Zhu, Linfang Lu, Zhigang Ni, Di Wu   +7 more
openaire   +2 more sources

Optimizing Cervical Cancer Classification with SVM and Improved Genetic Algorithm on Pap Smear Images [PDF]

Computer Science Journal of Moldova
This study presents an approach to optimize cervical cancer classification using Support Vector Machines (SVM) and an improved Genetic Algorithm (GA) on Pap smear images.
S. Umamaheswari, Y. Birnica, J. Boobalan, V. S. Akshaya   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Anaesthesia gas supply: Gas cylinders

Indian Journal of Anaesthesia, 2013
Invention of oxygen cylinder was one of the most important developments in the field of medical practice. Oxygen and other gases were compressed and stored at high pressure in seamless containers constructed from hand-forged steel in1880. Materials technology has continued to evolve and now medical gas cylinders are generally made of steel alloys or ...
openaire   +3 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Effects of Gibberellic acid, micronutrient fertilizer and Calcium nitrate foliar fertilizer on growth and yield of tomato Solanum lycopersicum L. cultivated in Vietnam

RUDN Journal of Agronomy and Animal Industries, 2019
In this study, we present the experimental results which evaluate the influence of Gibberellic acid GA3, micronutrient fertilizer and Calcium nitrate Ca(NO3)2 foliar fertilizer on the growth and yield of tomato cultivar NHP11 cultivated in a net house ...
Van Trong Le, Bao Thinh Bui
doaj   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Translation, adaptation and validation of the German version of the Game User Experience Satisfaction Scale (GUESS-GA-18) for adolescents

, 2023
The short version of the Game User Experience Satisfaction Scale (GUESS-18) uses nine factors to assess video game satisfaction. As video games play an important role for children and adolescents, the aim of this study was to translate and adapt the ...
Ina Krammer (10913435), Gloria Mittmann (10913429), Vanessa Zehetner (15468612), Beate Schrank (5178107)   +3 more
core   +1 more source