Results 191 to 200 of about 108,148 (261)

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen   +8 more
wiley   +1 more source

pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging

open access: yesAdvanced NanoBiomed Research, EarlyView.
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang   +11 more
wiley   +1 more source

Toward Cell‐Specific Molecular MRI: Modulating Chemical Exchange Saturation Transfer Contrast With Manganese

open access: yesAngewandte Chemie, EarlyView.
Manganese‐modulated chemical exchange saturation transfer (CEST) MRI, Manga CEST, leverages intracellular Mn2+ uptake to selectively perturb CEST contrast. Comparing Z‐spectra before and after Mn reveals compartment‐specific contributions. In vivo, neuron‐enriched Mn accumulation induces frequency‐dependent attenuation (3–4 ppm), enabling cell‐weighted
Eleonora Cavallari   +3 more
wiley   +1 more source

Redox‐Neutral Vicinal Dialkylation of Aryl Boronic Esters via the Palladium/Norbornene Cooperative Catalysis

open access: yesAngewandte Chemie, EarlyView.
A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye   +4 more
wiley   +1 more source

Rare‐Earth Multivariate Metal–Organic Frameworks: Cationic Radius Biased Compositional Control and Property Tuning

open access: yesAngewandte Chemie, EarlyView.
A family of multivariate metal–organic frameworks, UoB‐116(Ln), can be prepared using up to 16 different metals, revealing the ability to tune properties through compositional control. ABSTRACT The synthesis of a multivariate metal–organic framework (MTV‐MOF) family, [Ln(DNNDI)1.5]n (UoB‐116), is reported (DNNDI: N,N'‐bis(dinicotinate)‐1,4,5,8 ...
Adnan Ishaq   +9 more
wiley   +1 more source

Utility of Multi-Analyte Protein Assay to Distinguish Multiple Sclerosis Clinical Relapse from Pseudoexacerbation. [PDF]

open access: yesNeurol Ther
Okuda DT   +9 more
europepmc   +1 more source

Deciphering the Role of Energy Transfer Configuration in PFAS Recognition by Metal‐Organic Frameworks

open access: yesAngewandte Chemie, EarlyView.
Spatial organization of Eu/Tb centers in EuTb‐FDA MOFs is employed to regulate Tb‐to‐Eu energy transfer configuration for ratiometric PFAS sensing. Directional energy transfer amplifies PFAS‐induced optical perturbations into opposite lanthanide emission responses, with enhanced Tb emission and quenched Eu emission, thereby amplifying the sensing ...
Jiatong Huo   +5 more
wiley   +1 more source

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