Results 61 to 70 of about 3,869 (266)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Comparative Study of Spray-as-you-go Technique Using 2% versus 4% Lignocaine for Awake Fibre-optic Nasotracheal Intubation in Adult Oral Carcinoma Patients: A Randomised Controlled Study

Journal of Onco-Anaesthesiology and Perioperative Medicine
Background and Aims: Managing a difficult airway is a significant challenge for anaesthesiologists, with awake fibre-optic intubation being a highly effective technique.
H. G. Bhavana Priya, Manoj Kumar Chaurasiya, Aparna Shukla, Manish Kumar Singh, Monica Kohli   +4 more
doaj   +1 more source

Comparison of iatrogenic pain between rotavirus vaccination before and after vaccine injection in 2-month-old infants

Human Vaccines & Immunotherapeutics, 2017
Oral rotavirus vaccine (RV) administration in conjunction with other injectable vaccines has been used worldwide. However, whether the sequence of RV administration is associated with the reduction of injection-induced pain remains unclear.
Hui-Chu Yin, Whei-Mei Shih, Hsiu-Lan Lee, Huei-Jing Yang, Yu-Li Chen, Shao-Wen Cheng, Chun-Yuh Yang, Ya-Wen Chiu, Yi-Hao Weng   +8 more
doaj   +1 more source

Spontaneous Bleeding from a Short Gastric Artery after Vomiting Successfully Treated without Surgery

The Korean Journal of Gastroenterology, 2016
Spontaneous bleeding from a short gastric artery in the absence of pre-disposing trauma is reported very rarely. To the best of our knowledge, the published literature includes only 14 cases.
Seong Woo Hong, Yeo Goo Chang, Byungmo Lee, Woo Yong Lee   +3 more
doaj   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Randomised Comparative Study of Nalbuphine Propofol Versus Fentanyl-Propofol for Proseal Laryngeal Mask Airway Insertion

JK Science, 2022
Background: The purpose of the study was to compare the Proseal laryngeal mask airway (PLMA) insertion conditions and haemodynamic changes by using either Nalbuphine-propofol or Fentanyl-propofol.
Abhilasha Gupta, Ajay Gupta, Mukta Jitendra, Shruti Gupta   +3 more
doaj  

Treatment of Edentulous Patients Having Exaggerated Gag Reflex with Palateless Upper Denture

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2010
Gag reflex is one of the major problems that may face some complete denture wearer. This clinical study was conducted on twenty patients suffering from gagging reflex selected from hundreds attending teaching clinic of medical technical institute in ...
Sundus Ismail Al-azzawi, Raya Hatim Salal, Azhar Ahmed Mohammed Ali   +2 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Comparison of propofol (1%) with admixture (1:1) of thiopentone (1.25%) and propofol (0.5%) for laryngeal mask airway insertion in children undergoing elective eye surgery: Double-masked randomized clinical trial

Indian Journal of Anaesthesia, 2010
Intravenous propofol 1% has been the preferred agent for Laryngeal Mask Airway (LMA) insertion. Admixture of thiopentone 1.25% and propofol 0.5% (1:1) has been used by various authors for induction as well as insertion of LMA in adults.
Renu Sinha, Dilip Shende, Rakesh Garg
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source