ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin +8 more
wiley +1 more source
Identifying early key influencing factors of positive results in the early screening for postpartum depression with interpretable machine learning. [PDF]
Lin S +8 more
europepmc +1 more source
Associations of Sleep and Shift Work With Osteoarthritis Risk
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik +5 more
wiley +1 more source
Molecular fingerprints are strong models for peptide function prediction. [PDF]
Adamczyk J, Ludynia P, Czech W.
europepmc +1 more source
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah +8 more
wiley +1 more source
Spatial structure based deep feature fusion network for autism spectrum disorder classification. [PDF]
Shwetha KS +4 more
europepmc +1 more source
Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley +1 more source
Modelling precise responses to anti-seizure medication using brain organoids carrying SCN2A-GoF and SCN2A-LoF mutations. [PDF]
Yang Y +5 more
europepmc +1 more source
Prediction Pipeline Selection for Incomplete Clinical Data via Missingness Fingerprints and Instance Augmentation. [PDF]
Li R, Shen Z, Wu C, Li J, Tian Y.
europepmc +1 more source
Reliability-Aware Neural Decoding with Adaptive Multi-Source Information Fusion. [PDF]
Fu P +6 more
europepmc +1 more source

