Results 301 to 310 of about 705,710 (383)

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [¹¹C]PE2I PET study. [PDF]

Clin Park Relat Disord
Paalanen N, Roytman S, Emde Boas MV, Biddix A, Luker A, Michalakis F, Carli G, Kanel P, Pongmala C, Koeppe R, Chahine LM, Rosano C, Bohnen NI.   +12 more
europepmc   +1 more source

A three-dimensional geometric model of the knee for the study of joint forces in gait

, 1997
David R. Wilson, John O’Connor
openalex   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Long and unsatisfactory sleep associated with poor lower limb composition and physical performance in older adults. [PDF]

BMC Geriatr
Chen Z, Cui J, Tu F, Han Y, Zhang E, Zhang Y, Zhang T, Pang J.   +7 more
europepmc   +1 more source

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Advanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian, Jinguo Zhu, Yanwei He, Haocheng Qin, Pingkang Qian, Bingfeng Sun, Haoqiang Huang, Chen Kuang, Quan Yang, Yuxi Ou, Rong Sun, Feng Xu, Xianwen Wang, Zhiwen Luo, Qing Wang   +14 more
wiley   +1 more source

Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications

Advanced Electronic Materials, EarlyView.
This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster, Prashant Sankaran, Eloise Bihar   +2 more
wiley   +1 more source

Effect of altered gluteus maximus strength on the magnitude and direction of hip joint contact forces during simulations of gait. [PDF]

PLoS One
Patel JR, Grosklos M, Lewis CL, Di Stasi S.   +3 more
europepmc   +1 more source

Wireless Technologies for Wearable Electronics: A Review

Advanced Electronic Materials, EarlyView.
This review discusses recent advancements in wireless wearable electronics, focusing on communication technologies and power solutions. It covers key design considerations, explores wireless protocols from short‐ to long‐range networks, and examines powering methods such as integrated sources and energy harvesting.
Choong Yeon Kim, Juhyun Lee, Eun Young Jeong, Yeji Jang, Heesoo Kim, Bohyung Choi, Donggi Han, Youngjun Oh, Jae‐Woong Jeong   +8 more
wiley   +1 more source