Results 111 to 120 of about 18,928 (260)

Clustering Approaches for Gait Analysis within Neurological Disorders: A Narrative Review

Digital Biomarkers
Background: The prevalence of neurological disorders is increasing, underscoring the importance of objective gait analysis to help clinicians identify specific deficits. Nevertheless, existing technological solutions for gait analysis often suffer from impracticality in daily clinical use, including excessive cost, time constraints, and limited ...
Jonas Hummel, Michael Schwenk, Daniel Seebacher, Philipp Barzyk, Joachim Liepert, Manuel Stein   +5 more
openaire   +3 more sources

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Enhancing therapeutic decisions during robot-assisted gait therapy: current challenges and development of a novel app-based therapy protocol to address them

BMC Medical Informatics and Decision Making
Background Therapists’ decisions on influencing patient behavior during robot-assisted gait therapy directly impact clinical practice and, thus, therapeutic efficacy.
Florian van Dellen, Tabea Aurich, Rob Labruyère   +2 more
doaj   +1 more source

A Multifaceted Hybrid ES-Robotic Device for Gait Training in Individuals with Neurological Disorders

Nature Communications
Abstract The integration of robotics and Electrical Stimulation (ES) in neurorehabilitation combines the precise execution of complex tasks enabled by robotics with motor learning, muscle conditioning, and cardiovascular fitness induced by ES. We propose a hybrid lower-limb exoskeleton for gait training to maximize these benefits.
Francesca Dell’Eva, Eleonora Guanziroli, Viola Camerini, Marta Gandolla, Laura Brignole, Stefano Maludrottu, Emanuele Gruppioni, Giancarlo Ferrigno, Franco Molteni, Emilia Ambrosini, Alessandra Pedrocchi   +10 more
openaire   +2 more sources

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Feasibility and clinical integration study on low⁃cost digital gait analysis system based on dual Kinect V2

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To develop a low⁃cost digit⁃intelligent gait analysis system based on dual Kinect V2 sensors and universal open⁃source software platforms (DKS), and to evaluate its feasibility and accuracy for gait analysis. Methods A total of 15 patients with
ZHANG Shi⁃yu, CHEN Guo⁃rong, MAIMAITIABULA Saimaiti, XU Xing⁃hua, ZHUANG Jia⁃shu, CHEN Xiao⁃lei   +5 more
doaj   +1 more source

Evaluation of Gait Disorders Using Accelerometric and Gyroscopic Data for Assessment of Neurological Diseases

IEEE Access
Ministry of Health of Czech Republic [DRO-UHHK 00179906]; Charles University, Czech Republic (Cooperation Program, Research Area NEUR); European Union (EU) under the Project ROBOPROX in the area of Machine Learning [CZ.02.01.01/00/22_008/0004590]; Operational Program Johannes Amos Comenius financed by European Structural and Investment Funds; Czech ...
David Matyás, Libuse Smetanová, Oldrich Vysata, Tereza Tumová, Lucie Gonsorcikova, Hana Charvátová, Ales Procházka   +6 more
openaire   +2 more sources

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source