Results 51 to 60 of about 3,475 (159)

Assessing Cofactor Usage in Pseudoclostridium thermosuccinogenes via Heterologous Expression of Central Metabolic Enzymes

Frontiers in Microbiology, 2019
Pseudoclostridium thermosuccinogenes and Hungateiclostridium thermocellum are being studied for their potential to contribute to a more sustainable bio-based economy.
Jeroen Girwar Koendjbiharie, Kimberly Wevers, Richard van Kranenburg, Richard van Kranenburg   +3 more
doaj   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

Extracellular Vesicle‐Like Nanoparticles Present in Fermented Botanical Products Suppress Fat Absorption in the Gut

Journal of Food Science, Volume 90, Issue 9, September 2025.
ABSTRACT The fermented botanical product (FBP) is a complex, primarily plant‐based fermented food that has been popular among consumers for many years. Although FBP may modulate gastrointestinal function, the responsible factors and precise mechanisms remain unclear and speculative.
Kotomi Chikama, Koutarou Terada, Chika Yamamoto, Mana Yamamoto, Ayano Hojo, Kotaro Fujioka, Hideto Torii, Lee Wah Lim, Hiroshi Takemori   +8 more
wiley   +1 more source

Effects of Inhaled Lavender Essential Oil on Stress-Loaded Animals: Changes in Anxiety-Related Behavior and Expression Levels of Selected mRNAs and Proteins

Natural Product Communications, 2012
Inhalation of various essential oils elicits behavioral changes as a consequence of a complex centrally coordinated response. To understand the molecular mechanisms of action of aromatic compounds on emotional responses, we evaluated the stress-induced ...
Mizuho Takahashi, Akiharu Yoshino, Ayako Yamanaka, Chihiro Asanuma, Tadaaki Satou, Shinichiro Hayashi, Yoshinori Masuo, Kiyomi Sadamoto, Kazuo Koike   +8 more
doaj   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, Volume 15, Issue 8, Page 1336-1349, August 2025.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

GALDAR: A genetically encoded galactose sensor for visualizing sugar metabolism in vivo.

PLoS Biology
Sugar metabolism plays a pivotal role in sustaining life. Its dynamics within organisms is less understood compared to its intracellular metabolism. Galactose, a hexose stereoisomer of glucose, is a monosaccharide transported via the same transporters ...
Uğurcan Sakizli, Tomomi Takano, Sa Kan Yoo   +2 more
doaj   +1 more source

Strengthen or Weaken: Evolutionary Directions of Cross‐Feeding After Formation

Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.
There are two evolutionary directions for cross‐feeding consortia after formation: strengthening and weakening. Simultaneously, cross‐feeding reshapes the focal strain evolution from niche space, selective pressure, horizontal gene transfer, and evolutionary rate.
Laipeng Luo, Xiaoli Chen, Bingwen Liu, Yong Nie, Xiao‐Lei Wu   +4 more
wiley   +1 more source

Galactan mobilization during carbon starvation compromises plant cell wall‐mediated resistance to fungal infection

The Plant Journal, Volume 123, Issue 4, August 2025.
Significance Statement Polysaccharides present in plant cell walls must be dynamically modified in response to external stimuli, but it is not well understood how cell wall remodeling is adjusted in response to metabolic cues and how this affects defense against pathogens.
Louisa Reckleben, Richard N. Morton, Kristina S. Munzert‐Eberlein, Sabine Thiel, Carsten Rautengarten, Viviana Tan, Klara L. Harres, Lena Zanoni, Berit Ebert, Timo Engelsdorf   +9 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, Volume 599, Issue 11, Page 1609-1621, June 2025.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Results of the ACTION‐Galactosemia Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with Classic Galactosemia

The Journal of Clinical Pharmacology, Volume 65, Issue 5, Page 575-587, May 2025.
Abstract To evaluate the pharmacodynamic effects and clinical outcomes of orally administered once‐daily govorestat (AT‐007), a central nervous system penetrant aldose reductase inhibitor, the double‐blind placebo‐controlled ACTION‐Galactosemia Kids study (NCT04902781) randomly assigned 47 participants (2‐17 years old) with Classic Galactosemia to 18 ...
Evan Bailey, Han Phan, Ayesha Ahmad, Janet Thomas, Elizabeth G. Ames, Amanda B. Pritchard, Shane C. Quinonez, Stella Wang, Caleb Dayley, Andrew Salt, Christina Pick, Abe Durrant, Samuel Johnson, Jessie Nicodemus‐Johnson, Samuel P. Dickson, Riccardo Perfetti, Suzanne B. Hendrix, Shoshana Shendelman   +17 more
wiley   +1 more source