Results 191 to 200 of about 2,216 (262)

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Primordial Rotating Disk Composed of ≥15 Star Forming Clumps at Cosmic Dawn

Fujimoto S, Ouchi M, Kohno K, Valentino F, Giménez-Arteaga C, Brammer G, Furtak L, Kohandel M, Oguri M, Pallottini A, Richard J, Zitrin A, Bauer F, Boylan-Kolchin M, Dessauges-Zavadsky M, Egami E, Finkelstein S, Ma Z, Smail I, Watson D, Hutchison T, Rigby J, Welch B, Ao Y, Bradley L, Caminha G, Caputi K, Espada D, Endsley R, Fudamoto Y, González-López J, Hatsukade B, Koekemoer A, Kokorev V, Laporte N, Lee M, Magdis G, Ono Y, Rizzo F, Shibuya T, Shimasaku K, Sun F, Toft S, Umehata H, Wang T, Yajima H.   +45 more
europepmc   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Resolving the hot and ionized Universe through the Sunyaev-Zeldovich effect. [PDF]

Open Res Eur
Di Mascolo L, Perrott Y, Mroczkowski T, Andreon S, Ettori S, Simionescu A, Raghunathan S, van Marrewijk J, Cicone C, Lee M, Nelson D, Sommovigo L, Booth M, Klaassen P, Andreani P, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone TJ, Morris TW, Saintonge A, Smith M, Thelen AE, Wedemeyer S.   +24 more
europepmc   +1 more source

H2 MAGIE: H2 as a Major Agent to Galaxy Interaction and Evolution

, 2010
P. Guillard
openalex   +2 more sources

Light Quantity Impacts Early Response to Cold and Cold Acclimation in Young Leaves of Arabidopsis

Plant, Cell &Environment, Volume 48, Issue 7, Page 5030-5052, July 2025.
ABSTRACT Plant reactions to stress vary with development stage and fitness. This study assessed the relationship between light and chilling stress in Arabidopsis acclimation. By analysing the transcriptome and proteome responses of expanding leaves subjected to varying light intensity and cold, 2251 and 2064 early response genes and proteins were ...
Markéta Luklová, Marieke Dubois, Michaela Kameniarová, Klára Plačková, Jan Novák, Romana Kopecká, Michal Karady, Jaroslav Pavlů, Jan Skalák, Sunita Jindal, Ljiljana Tubić, Zainab Quddoos, Ondřej Novák, Dirk Inzé, Martin Černý   +14 more
wiley   +1 more source

Fundamental physics, existential risks and human futures. [PDF]

Philos Trans A Math Phys Eng Sci
Kent A.
europepmc   +1 more source

Silicosarcoidosis: Histologic and Clinical Features of an Occupational Granulomatous Disease

American Journal of Industrial Medicine, Volume 68, Issue 6, Page 491-507, June 2025.
ABSTRACT Sarcoidosis is a multisystem inflammatory disease of unknown etiology. Growing evidence indicates that occupational exposure to respirable crystalline silica (RCS) is associated with an increased incidence of sarcoidosis. Yet a diagnosis of sarcoidosis rarely prompts investigation to identify preventable exposures.
Jeremy T. Hua, Carlyne D. Cool, Einat Fireman Klein, Yochai Adir, Lukas J. Lee, Lauren M. Zell‐Baran, Robert A. Cohen, Richard C. Kraus, E. Brigitte Gottschall, Silpa D. Krefft, Charles Van Hook, Cecile S. Rose   +11 more
wiley   +1 more source

Neutrinos to Astrovirology: Signatures. [PDF]

Bioinformation
Shapshak P, Zandi M, Somboonwit C, Sinnott JT.   +3 more
europepmc   +1 more source

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

iMeta, Volume 4, Issue 3, June 2025.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng   +17 more
wiley   +1 more source

The microbiologist's guide to metaproteomics

iMeta, Volume 4, Issue 3, June 2025.
Metaproteomics within the multi‐omics framework provides a comprehensive view of microbial systems by identifying proteins, quantifying their levels, detecting posttranslational modifications (PTMs), mapping protein–protein interactions (PPIs), and localizing proteins.
Tim Van Den Bossche, Jean Armengaud, Dirk Benndorf, Jose Alfredo Blakeley‐Ruiz, Madita Brauer, Kai Cheng, Marybeth Creskey, Daniel Figeys, Lucia Grenga, Timothy J. Griffin, Céline Henry, Robert L. Hettich, Tanja Holstein, Pratik D. Jagtap, Nico Jehmlich, Jonghyun Kim, Manuel Kleiner, Benoit J. Kunath, Xuxa Malliet, Lennart Martens, Subina Mehta, Bart Mesuere, Zhibin Ning, Alessandro Tanca, Sergio Uzzau, Pieter Verschaffelt, Jing Wang, Paul Wilmes, Xu Zhang, Xin Zhang, Leyuan Li, The Metaproteomics Initiative   +31 more
wiley   +1 more source