Results 61 to 70 of about 1,726 (201)

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

PanGraphRNA: An efficient and flexible bioinformatics platform for graph pangenome‐based RNA‐seq data analysis

Journal of Integrative Plant Biology, EarlyView.
PanGraphRNA is an easy‐to‐use platform that improves RNA‐seq analysis by using graph pangenomes instead of a single reference genome. It increases read alignment accuracy, detects important genes missed by traditional methods, and works across major crops, helping researchers obtain more reliable transcriptome results for diverse plant research and ...
Yifan Bu, Zhixu Qiu, Wen Sun, Yishui Han, Yifan Liu, Jing Yang, Minggui Song, Zenglin Li, Songyu Liu, Yuzhou Zhang, Chuang Ma   +10 more
wiley   +1 more source

A role for core facilities in improving research rigour

Journal of Microscopy, EarlyView.
Abstract Scientific reproducibility is an ethical and societal responsibility. Discussions of reproducibility and repeatability often focus on the roles of stakeholders in the scientific process, including researchers, publishers, and funders. Core facility staff have distinct functions in research planning, training, interpretation and oversight which
Alison J. North, Kurt I. Anderson
wiley   +1 more source

Automation and Augmentation in Theological Perspective

Modern Theology, EarlyView.
Abstract AI enables forms of automation that threaten unemployment and deskilling, eliminating important opportunities for the development of virtue. The concomitant loss of virtue and meaningful employment makes it a theological problem from the perspective of Catholic social teaching and theological anthropology.
Paul Scherz
wiley   +1 more source

Harnessing Bulk‐Segregant Mapping to Identify Trait‐Associated Genes in the Allopolyploid Model Plant Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Forward genetics has been instrumental in identifying genes underlying desirable traits, yet its application to polyploid plants, many of which are key agricultural crops, remains challenging due to their genomic complexity. Therefore, we developed BenthMap, a bulk segregant analysis platform for high‐throughput trait mapping and gene ...
Zuba Ahmed, Jiyuan An, Satomi Hayashi, Julia Bally, Chris Winefield, Peter M. Waterhouse   +5 more
wiley   +1 more source

Challenges in Bringing Pangenome Research Into Breeding: A Case Study in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Crop breeding has entered the pangenomics era, unlocking a far more comprehensive view of genetic diversity than a single reference genome can capture. In rice (Oryza sativa), a staple crop critical to global food security, the construction of pangenome resources has uncovered extensive structural variations (SVs), presence/absence variations (
Shuai Nie, Fangping Li, Risheng Li, Jian Wang, Yamei Ma, Chon Kit Kenneth Chan, Junliang Zhao, Haifei Hu   +7 more
wiley   +1 more source

Is Less More? Field Evidence on the Impact of Anti‐Bribery Policies on Employee Knowledge and Corrupt Behavior

Regulation &Governance, EarlyView.
ABSTRACT Companies increasingly adopt internal norms to enhance compliance with legal rules. However, the rapid growth in volume and complexity of such internal rules may obstruct employee knowledge and understanding of such internal rules, and therefore also their compliance.
Nils Köbis, Sharon Oded, Anne Leonore de Bruijn, Shuyu Huang, Benjamin van Rooij   +4 more
wiley   +1 more source

Low‐dose X‐ray radiation induces an adaptive response: A potential countermeasure to galactic cosmic radiation exposure

Experimental Physiology, EarlyView.
Abstract Space exploration involves many dangers including galactic cosmic radiation (GCR). This class of radiation includes high‐energy protons and heavy ionizing ions. NASA has defined GCR as a carcinogenic risk for long‐duration space missions. To date, no clear strategy has been developed to counter chronic GCR exposure.
Siena Edwards, Jessica Adams, Anastasia Tchernikov, John G. Edwards   +3 more
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright

Experimental Physiology, EarlyView.
Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo, Christina Lysandrou, Laura Sudres, Alfonso Gil‐Martinez, Jaap Swanenburg, James Edward Clark, David Andrew Green   +6 more
wiley   +1 more source