Results 181 to 190 of about 1,938,921 (284)

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

open access: yesBiotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2457-2481, October 2026.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva   +8 more
wiley   +1 more source

Genome‐Wide Identification and Structural Characterization of Secondary Metabolite Biosynthetic Gene Clusters in African Baobab (Adansonia digitata)

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Genome‐wide computational analysis of the African baobab (Adansonia digitata) identifies 50 candidate biosynthetic gene clusters spanning terpene, polyketide, cyclopeptide, and lignan pathways, including nine BURP‐domain clusters linked to putative chemical defense.
Ahmed A. Elshikh   +2 more
wiley   +1 more source

The abundance and radial distribution of faint and ultra-faint dwarfs in galaxy clusters. [PDF]

open access: yesMon Not R Astron Soc
Sadhu P   +5 more
europepmc   +1 more source

Does Mother Provide? Re‐Examination of Maternal and Embryonic Microbiomes of Diploptera punctata

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
This figure summarizes the compositional differences in the non‐blattabacterial microbiomes of embryonic and adult females of the viviparous, Diploptera punctata. This shows the non‐negligible presence and possibly maternal sources of these bacterial taxa in developing embryos.
Brennan Jonas   +2 more
wiley   +1 more source

Trp53 Deficiency Increases the Frequency of Hprt Mutant T Lymphocytes Following High‐LET Iron Particle Irradiation of Mice

open access: yesEnvironmental and Molecular Mutagenesis, Volume 67, Issue 8-9, October‐November 2026.
ABSTRACT Charged particles like iron‐56 ions impose health risks in long‐term manned space exploration. This study was designed to define the impact of Trp53 status upon the manifestation of mutations in the hypoxanthine‐guanine phosphoribosyltransferase (Hprt) gene in splenic T‐cells following exposure of Trp53 wild‐type, hemizygous, and nullizygous ...
Vernon E. Walker   +3 more
wiley   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan   +6 more
wiley   +1 more source

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