Socioeconomic inequalities in receipt of curative‐intent treatment and survival persist among individuals with surveillance‐detected HCC within a universal healthcare system. These findings suggest that surveillance alone is insufficient to ensure equitable outcomes and highlight the need for strategies addressing social determinants across the care ...
Hannes Hagström +6 more
wiley +1 more source
Association of surgical extent with survival in locally advanced gallbladder cancer based on propensity score matching. [PDF]
Gu J, Han J, Zhang Y, Tian Y.
europepmc +1 more source
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama +20 more
wiley +1 more source
MET Amplification in Gallbladder Cancer: a Case Report on a Precision Medicine Approach with Glumetinib and Envafolimab. [PDF]
Wu XJ, Nie X, Xu JF, Gui RJ, Duan HX.
europepmc +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
Supramolecular coordination nanoplatform amplifies oxidative stress to overcome ferroptosis resistance in gallbladder cancer. [PDF]
Zhao Y +13 more
europepmc +1 more source
Emerging Techniques in Minimally Invasive Surgery in Hematologic Malignancies
ABSTRACT Hematologic malignancies represent the most common cancers in children. While the mainstays of treatment are chemotherapy and potentially hematopoietic stem cell transplant, minimally invasive surgery (MIS) has a role in the diagnosis and management of complications related both to disease and therapy as well as common pediatric surgical ...
Alejandro Chara +3 more
wiley +1 more source
Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer. [PDF]
Zhao C +11 more
europepmc +1 more source
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello +20 more
wiley +1 more source
ERBB2 I655V mutation correlates with efficacy of immunotherapy in gallbladder cancer. [PDF]
Gao Q +5 more
europepmc +1 more source

