Results 271 to 280 of about 90,478 (344)

Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant‐Induced Toxicities: A Systematic Review of Animal Studies

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Pollutant‐induced epithelial damage also leads to a cascade of harmful effects, including reduced mucus secretion, decreased luminal pH, and enhanced absorption of toxins. These changes contribute to oxidative stress (↑ malondialdehyde (MDA); ↓ superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and heightened ...
Meysam Zarezadeh Ph.D., Ahmad Saedisomeolia, Mahsa Mahmoudinezhad, Michele M. Iskandar, Fang Lu, Stan Kubow   +5 more
wiley   +1 more source

Unveiling the causative role of promoter variant rs113823671 in MMP7 in gallbladder cancer susceptibility. [PDF]

Sci Rep
Jeeyar V, Besra K, Singh SP, Dixit M.
europepmc   +1 more source

Characterizing Apixaban Pharmacokinetics Through Physiologically‐Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Apixaban, a factor Xa inhibitor, is a direct oral anticoagulant with a well‐balanced elimination; it is eliminated evenly via feces, urine (with no active secretion), and as metabolites after oral administration. The common understanding is that biliary secretion and enterohepatic circulation (EHC) of apixaban are limited in humans, and that ...
Toshiaki Tsuchitani, Wen Kou, Masatoshi Tomi, Yuichi Sugiyama   +3 more
wiley   +1 more source

HER2-targeted therapy combined with multidisciplinary management in advanced gallbladder cancer: a case report with 90-month survival. [PDF]

Front Oncol
Wang Y, Tian G, Cheng Y, Wu S, Wei Y, Fan S, Qu J, Wang J.   +7 more
europepmc   +1 more source

Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With 225Ac‐ and 177Lu‐Labeled RGD Peptides

Cancer Science, Volume 117, Issue 1, Page 193-202, January 2026.
Radionuclide therapy using PD‐K(225Ac‐DOTA)‐RGD in BxPC‐3‐bearing mice. PD‐K(225Ac‐DOTA)‐RGD successfully suppressed tumor growth. ABSTRACT Improved peptide pharmacokinetics are needed to enhance the therapeutic effects of peptide‐based radionuclide therapy.
Mitsuyoshi Yoshimoto, Shun‐ichi Wada, Yukie Yoshii, Sayaka Hanadate, Anri Inaki, Hirofumi Fujii   +5 more
wiley   +1 more source

Early detection of gallbladder cancer: Current status and future perspectives. [PDF]

World J Clin Oncol
Sarangi Y, Kumar A.
europepmc   +1 more source

lncDILC Downregulation in Liver Cancer‐Associated Fibroblasts Drives Pro‐Invasive Conversion via a miR‐6071‐ZNF395 Axis

Cancer Science, Volume 117, Issue 1, Page 145-155, January 2026.
We found in the present study the loss‐of‐function of a sequential inhibitory cascade of lncDILC‐miR‐6071‐ZNF395 in liver CAFs, which promoted the NF‐CAF conversion through increasing expression of pro‐invasive cytokines like IL‐6, LIF, CXCL12, and TGF‐β.
Yawen Li, Jilong Liu, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu, Guoqing Shi, Xuemei Liu   +7 more
wiley   +1 more source

The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population. [PDF]

Front Oncol
Erices JI, González E, Salgado M, Barahona-Ponce C, Freire M, Sepúlveda-Hermosilla G, Ampuero D, Blanco A, Gárate-Calderón V, Báez-Benavides P, Tapia-Valladares C, Toro J, Gallegos I, Barajas O, Ahumada M, Sanhueza V, Spencer L, De Toro G, Morales E, Gutiérrez L, Morales F, Marin A, Varela NM, Lorenzo Bermejo J, Armisén R, Marcelain K.   +25 more
europepmc   +1 more source

Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 174-185, January 2026.
Abstract Aim Metabolic bariatric surgery (MBS) improves histological endpoints in steatotic liver disease (SLD), but data on longer‐term clinical outcomes in this population are scarce. Here, we assessed the impact of MBS on hepatic and extrahepatic morbidity and mortality in individuals with SLD.
Weronika Stupalkowska, Alexander Henney, Eric G. Sheu, Uazman Alam, Daniel J. Cuthbertson   +4 more
wiley   +1 more source

Perioperative red blood cell transfusion in gallbladder cancer surgery: Trends and determinants from nationwide data. [PDF]

Ann Hepatobiliary Pancreat Surg
Yoon J, Kim S, Hong S, Jung YK, Choi D, Park B.   +5 more
europepmc   +1 more source